COVID-19 and β-thalassemia: in lieu of evidence and vague nexus

被引：0
作者：
Hayder M. Al-Kuraishy
Mohamed H. Mazhar Ashour
Hebatallah M. Saad
Gaber El-Saber Batiha
机构：
[1] Al-Mustansiriyiah University,Department of Clinical Pharmacology and Therapeutic Medicine, College of Medicine
[2] Tanta University,General and Pediatric Surgery, Faculty of Medicine
[3] Matrouh University,Department of Pathology, Faculty of Veterinary Medicine
[4] Damanhour University,Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine
来源：
Annals of Hematology | 2024年 / 103卷
关键词：
SARS-CoV-2; COVID-19; β-thalassemia; Pro-inflammatory activation; Cytokine storm; Autosomal recessive disorders;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Coronavirus disease 19 (COVID-19) is an infectious disease caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) causing acute systemic disorders and multi-organ damage. β-thalassemia (β-T) is an autosomal recessive disorder leading to the development of anemia. β-T may lead to complications such as immunological disorders, iron overload, oxidative stress, and endocrinopathy. β-T and associated complications may increase the risk of SARS-CoV-2, as inflammatory disturbances and oxidative stress disorders are linked with COVID-19. Therefore, the objective of the present review was to elucidate the potential link between β-T and COVID-19 regarding the underlying comorbidities. The present review showed that most of the β-T patients with COVID-19 revealed mild to moderate clinical features, and β-T may not be linked with Covid-19 severity. Though patients with transfusion-dependent β-T (TDT) develop less COVID-19 severity compared to non-transfusion-depend β-T(NTDT), preclinical and clinical studies are recommended in this regard.
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页码：1423 / 1433
页数：10
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