Incidence of squamous neoplasia of the cervix and vagina in women exposed prenatally to diethylstilbestrol (United States)

被引:0
作者
E. E. Hatch
A. L. Herbst
R. N. Hoover
K. L. Noller
E. Adam
R. H. Kaufman
J. R. Palmer
L. Titus-Ernstoff
M. Hyer
P. Hartge
S. J. Robboy
机构
[1] National Cancer Institute,Division of Cancer Epidemiology and Genetics
[2] University of Chicago,Department of Obstetrics and Gynecology
[3] University of Massachusetts Medical Center,Department of Obstetrics and Gynecology
[4] Baylor College of Medicine,Department of Obstetrics and Gynecology
[5] Boston University School of Public Health,Slone Epidemiology Unit
[6] Dartmouth-Hitchcock Medical Center,Norris Cotton Cancer Center
[7] Information Management Services,Departments of Pathology and Obstetrics and Gynecology
[8] Duke University Medical Center,undefined
来源
Cancer Causes & Control | 2001年 / 12卷
关键词
Cervix; diethylstilbestrol; cohort study; squamous neoplasia; vagina;
D O I
暂无
中图分类号
学科分类号
摘要
Objectives: Women exposed prenatally to diethylstibestrol (DES) have an excess risk of clear-cell adenocarcinoma of the vagina and cervix, but the effect on the incidence of squamous neoplasia is uncertain. The purpose of the current study was to evaluate the long-term risk of developing high-grade squamous neoplasia of the genital tract among women exposed prenatally to DES.
引用
收藏
页码:837 / 845
页数:8
相关论文
共 60 条
  • [1] Herbst AL(1971)Adenocarcinoma of the vagina: association of maternal stilbestrol therapy with tumor appearance in young women N Engl J Med 284 878-881
  • [2] Ulfelder H(1979)Pathologic findings in young women enrolled in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project Obstet Gynecol 53 309-317
  • [3] Poskanzer DC(1979)Vaginal epithelial changes in young women enrolled in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project Obstet Gynecol 53 300-308
  • [4] Robboy SJ(1976)Cancer risk in diethylstilbestrol-exposed offspring Am J Obstet Gynecol 126 543-548
  • [5] Kaufman RH(1981)Dysplasia and cytologic findings in 4,589 young women enrolled in Diethylstilbestrol-Adenosis (DESAD) Project Am J Obstet Gynecol 140 579-586
  • [6] Prat J(1984)Increased incidence of cervical and vaginal dysplasia in 3,980 diethylstilbestrol-exposed young women. Experience of the National Collaborative Diethylstilbestrol Adenosis Project JAMA 252 2979-2983
  • [7] O'Brien P(2000)Prevalence of gynecologic cancer in women exposed to diethylstilbestrol N Engl J Med 342 1838-1839
  • [8] Noller KL(1998)Cancer risk in women exposed to diethylstilbestrol JAMA 280 630-634
  • [9] Robboy SJ(1978)Design and preliminary observations of the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project Obstet Gynecol 51 453-458
  • [10] Mattingly RF(1953)Does the administration of diethylstilbestrol during pregnancy have therapeutic value? Am J Obstet Gynecol 66 1062-1081