Combined hepatocholangiocarcinoma: Case-series and review of literature

被引：18
作者：
Bhagat V. [1 ]
Javle M. [1 ]
Yu J. [4 ]
Agrawal A. [1 ]
Gibbs J.F. [2 ]
Kuvshinoff B. [2 ]
Nava E. [3 ,5 ]
Iyer R. [1 ,5 ]
机构：
[1] Department of Medicine, Roswell Park Cancer Institute, Buffalo
[2] Department of Surgery, Roswell Park Cancer Institute, Buffalo
[3] Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, Elm and Carlton Streets
[4] Department of Biostatistics, State University at Buffalo, Buffalo
[5] Roswell Park Cancer Institute, Buffalo, NY 14263, Elm and Carlton Streets
来源：
International Journal of Gastrointestinal Cancer | 2006年 / 37卷 / 1期
关键词：
Cholangiocarcinoma; Hepatocellular carcinoma; Hepatocholangiocarcinoma;
D O I：
10.1385/IJGC:37:1:27
中图分类号：
学科分类号：
摘要：
Background and Aim: Combined hepatocholangiocarcinoma (CHCC) is an infrequent primary hepatic malignancy with no clearly defined diagnostic criteria, poorly studied natural history, and no guidelines regarding therapy. In this study we attempted to address this need and review our experience. Methods and Results: We performed a retrospective review of all CHCC cases at our institute over the last 10 yr. Eight cases were identified; histological and immunohistochemical criteria used for diagnosis were defined. Patients characteristics were: median age 65 yr (range 47-80); five females; risk factors-cholelithiasis (n = 4) and cirrhosis due to chronic viral hepatitis B and C (n = 1). Abdominal pain (n = 6), hepatomegaly (n = 4), and elevated CA 19-9 >40 U/mL (n = 4/5) were frequent. Early TNM stage (I and II) compared with advanced disease (III and IV) correlated with higher overall survival on univariate analyses [37 and 6 mo respectively (p = 0.011)]. Median overall survival was significantly higher in patients who underwent potentially curative resection (23 mo, range 4-48+) compared with patients who underwent non-surgical therapies such as transcatheter arterial chemoembolization and chemotherapy (2 mo, range 1-8) (p = 0.0357, one-sided exact log-rank test). Conclusions: Chronic inflammation and cirrhosis may play a role in pathogenesis of CHCC. Surgical resection and early stage at diagnosis predict longer survival. © Copyright 2006 by Humana Press Inc. All rights of any nature whatsoever reserved.
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页码：27 / 34
页数：7
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