Hepatic involvement in wegener's granulomatosis: A case report

被引：5

作者：

Goritsas C. ^{[1
]}

Paissios N.P. ^{[1
]}

Trigidou R. ^{[2
]}

Delladetsima J. ^{[3
]}

机构：

[1] Department of Internal Medicine, Sotiria General Hospital, Athens 11527

[2] Department of Pathology, Sotiria General Hospital, Athens 11527

[3] Department of Pathology, Laiko University Hospital, Ag Thoma

来源：

Journal of Medical Case Reports | / 4卷 / 1期

关键词：

Primary Biliary Cirrhosis; Portal Tract; Cefprozil; Myoclonus Epilepsy; Liver Function Study;

D O I：

10.1186/1752-1947-4-9

中图分类号：

学科分类号：

摘要：

Introduction. We report the case of a 58-year-old Caucasian Greek man who presented with dry cough, fever, bilateral alveolar infiltrates and acute hepatitis. Case presentation. After a lung biopsy, the patient was diagnosed with Wegener's granulomatosis. The diagnosis was supported by the presence of anti-proteinase-3 anti-neutrophil cytoplasmic antibodies. A liver biopsy demonstrated the presence of mild non-specific lobular hepatitis and periodic acid-Schiff positive Lafora-like inclusions in a large number of his liver cells. The patient was treated with prednisone and cyclophosphamide, which was followed by subsequent remissions of chest X-ray findings and liver function studies. Conclusion. What makes this case worth reporting is the coexistence of liver inflammation with a biochemical profile of severe anicteric non-viral, non-drug induced hepatitis coinciding with the diagnosis of Wegener's granulomatosis. Our paper may be the first report of hepatic involvement in a patient diagnosed with Wegener's granulomatosis. The aetiological link between the two diseases is supported by the reversion of hepatitis after the immunosuppression of Wegener's granulomatosis. We favor the hypothesis that hepatic vasculitis may be the cause of acute hepatocellular necrosis. © 2010 Goritsas et al; licensee BioMed Central Ltd.

引用

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