Regenerative Medicine in the Cornea

被引:0
作者
Simpson F.C. [1 ]
Griffith M. [1 ,2 ]
机构
[1] Direction de la Recherche, Hôpital Maisonneuve-Rosemont, Polyclinique, 305, 5415 Boulevard de l’Assomption, Montréal, H1T 2M4, QC
[2] Department of Ophthalmology, Université de Montréal, Montréal, QC
关键词
Bioengineering; Biomaterials; Clinical studies; Cornea; Stem cells;
D O I
10.1007/s40135-017-0140-5
中图分类号
学科分类号
摘要
Purpose of Review: Corneal disease affects 12.7 million individuals globally, and the current gold standard therapy using a human donor cornea (HDC) in low-risk patients or keratoprosthesis in high-risk patients is prone to graft rejection. New techniques are currently being investigated to regenerate corneal tissue to provide a more effective treatment for corneal blindness. Recent Findings: Research into corneal regeneration falls broadly into three categories: cell-based therapies using autografts or allografts expanded in culture, material-based therapies that provide fully synthetic scaffolds, and cell-biomaterial composites that combine both strategies. Progress has been made developing tissue-specific solutions and multilayer grafts to target specific types of corneal disease. Summary: All three classes of therapies have shown progress. The recent European approval of “Holoclar” composite autografts and the phase I clinical trials of fully synthetic corneas demonstrate that research in this field is being actively translated into clinical practice. © 2017, Springer Science + Business Media New York.
引用
收藏
页码:187 / 192
页数:5
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