Dual Antiplatelet Therapy in Coronary Artery Disease

被引：31

作者：

Sharma, Raghav ^{[1
]}

Kumar, Prathap ^{[2
]}

Prashanth, S. P. ^{[3
]}

Belagali, Yogesh ^{[3
]}

机构：

[1] Meditrina Hosp, Civil Hosp, Ambala, Haryana, India

[2] Meditrina Hosp, Ayoor Rd, Kollam, Kerala, India

[3] AstraZeneca, Med Affairs Div, Bangalore, Karnataka, India

来源：

CARDIOLOGY AND THERAPY | 2020年 / 9卷 / 02期

关键词：

Clopidogrel; Coronary artery disease; Dual antiplatelet therapy; Prasugrel; Switching between antiplatelets; Ticagrelor; ELEVATION MYOCARDIAL-INFARCTION; CARDIOVASCULAR EVENTS; FOCUSED UPDATE; INTERVENTION; CLOPIDOGREL; TICAGRELOR; PRASUGREL; ASIA; ACS; MONOTHERAPY;

D O I：

10.1007/s40119-020-00197-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute coronary syndrome (ACS) is principally driven by platelet aggregation. Dual antiplatelet therapy (DAPT) has demonstrated a reduction in recurrent ischemic events. The newer antiplatelets ticagrelor and prasugrel have demonstrated superiority over clopidogrel. While prasugrel demonstrated benefit in patients scheduled for percutaneous intervention (PCI), benefits of ticagrelor were seen irrespective of the treatment strategy. Current guidelines recommend the use of DAPT for 1 year in all patients with ACS. Ticagrelor 60 mg is recommended for up to 3 years in high-risk patients. DAPT and Predicting Bleeding Complications in Patients Undergoing Stent Implantation and Subsequent Dual Antiplatelet Therapy (PRECISE DAPT) scores are tools to support decision-making in deciding duration of dual antiplatelet therapy.

引用

页码：349 / 361

页数：13

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