Varied functions of immune checkpoints during cancer metastasis

被引：0
作者：
Ali Safarzadeh
Mohsen Alizadeh
Fatemeh Beyranvand
Reza Falavand Jozaaee
Khalil Hajiasgharzadeh
Amir Baghbanzadeh
Afshin Derakhshani
Antonella Argentiero
Behzad Baradaran
Nicola Silvestris
机构：
[1] Tabriz University of Medical Sciences,Immunology Research Center
[2] Lorestan University of Medical Sciences,Student Research Committee
[3] IRCCS IstitutoTumori “Giovanni Paolo II” of Bari,Department of Biomedical Sciences and Human Oncology
[4] University of Bari “Aldo Moro”,undefined
来源：
Cancer Immunology, Immunotherapy | 2021年 / 70卷
关键词：
Immune checkpoints; Metastasis; Tumor; Immune system;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Immune checkpoints comprise diverse receptors and ligands including costimulatory and inhibitory molecules, which play monumental roles in regulating the immune system. Immune checkpoints retain key potentials in maintaining the immune system homeostasis and hindering the malignancy development and autoimmunity. The expression of inhibitory immune checkpoints delineates an increase in a plethora of metastatic tumors and the inhibition of these immune checkpoints can be followed by promising results. On the other hand, the stimulation of costimulatory immune checkpoints can restrain the metastasis originating from diverse tumors. From the review above, key findings emerged regarding potential functions of inhibitory and costimulatory immune checkpoints targeting the metastatic cascade and point towards novel potential Achilles’ heels of cancer that might be exploited therapeutically in the future.
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页码：569 / 588
页数：19
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