Preference of Oral Tenofovir Disoproxil Fumarate/Emtricitabine Versus Rectal Tenofovir Reduced-Glycerin 1% Gel Regimens for HIV Prevention Among Cisgender Men and Transgender Women Who Engage in Receptive Anal Intercourse with Men

被引：0

作者：

Alex Carballo-Diéguez

Rebecca Giguere

Curtis Dolezal

Cheng-Shiun Leu

Iván C. Balán

William Brown

Christine Rael

Barbra A. Richardson

Jeanna M. Piper

Linda-Gail Bekker

Suwat Chariyalertsak

Anupong Chitwarakorn

Pedro Gonzales

Timothy H. Holtz

Albert Liu

Kenneth H. Mayer

Carmen D. Zorrilla

Javier R. Lama

Ian McGowan

Ross D. Cranston

机构：

[1] Columbia University,HIV Center for Clinical and Behavioral Studies at New York State Psychiatric Institute

[2] University of California San Francisco,Department of Medicine, Center for AIDS Prevention Studies

[3] Zuckerberg San Francisco General Hospital,UCSF Center for Vulnerable Populations, Health Communications Research Program

[4] University of Washington,Department of Biostatistics

[5] National Institute of Allergy and Infectious Diseases,Division of AIDS

[6] University of Cape Town,Desmond Tutu HIV Centre

[7] Chiang Mai University,Research Institute for Health Sciences

[8] Thailand Ministry of Public Health – U.S. Centers for Disease Control and Prevention Collaboration,The Fenway Institute, Harvard Medical School

[9] Asociación Civil Impacta Salud y Educación,Department of Obstetrics and Gynecology

[10] U.S. Centers for Disease Control and Prevention,School of Medicine

[11] San Francisco Department of Public Health,undefined

[12] Beth Israel Deaconess Medical Center,undefined

[13] University of Puerto Rico School of Medicine,undefined

[14] University of Pittsburgh,undefined

[15] Unit 15,undefined

[16] New York State Psychiatric Institute,undefined

来源：

AIDS and Behavior | 2017年 / 21卷

关键词：

Acceptability; Gel; PrEP; Microbicide; Rectal;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Oral pre-exposure prophylaxis (PrEP) can prevent HIV transmission. Yet, some may prefer not to take systemic daily medication. MTN-017 was a 3-period, phase 2 safety and acceptability study of microbicide gel applied rectally either daily or before and after receptive anal intercourse (RAI), compared to daily oral tablet. At baseline, cisgender men and transgender women who reported RAI (N = 187) rated the daily oral regimen higher in overall liking, ease of use, and likelihood of future use than the gel regimens. After trying all three, 28% liked daily oral the least. Gel did not affect sexual enjoyment (88%) or improved it (7–8%). Most partners had no reaction to gel use. Ease of gel use improved significantly between the first and the last few times of daily use. A rectal gel used before and after RAI may constitute an attractive alternative to daily tablet. Experience with product use may increase acceptability.

引用

页码：3336 / 3345

页数：9

共 61 条

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