Lysosomes in cell death

被引:0
|
作者
Maria Eugenia Guicciardi
Marcel Leist
Gregory J Gores
机构
[1] Mayo Clinic College of Medicine,
[2] H. Lundbeck A/S,undefined
来源
Oncogene | 2004年 / 23卷
关键词
cathepsins; Spi2A; TNF;
D O I
暂无
中图分类号
学科分类号
摘要
For many years apoptosis research has focused on caspases and their putative role as sole executioners of programmed cell death. Accumulating information now suggests that lysosomal cathepsins are also pivotally involved in this process, especially in pathological conditions. In particular, the role of lysosomes and lysosomal enzymes in initiation and execution of the apoptotic program has become clear in several models, to the point that the existence of a ‘lysosomal pathway of apoptosis’ is now generally accepted. This pathway of apoptosis can be activated by death receptors, lipid mediators, and photodamage. Lysosomal proteases can be released from the lysosomes into the cytosol, where they contribute to the apoptotic cascade upstream of mitochondria. This review focuses on the players and the molecular mechanisms involved in the lysosomal pathway of apoptosis as well as on the importance of this pathway in development and pathology.
引用
收藏
页码:2881 / 2890
页数:9
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