Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c

被引：0
|
作者：
Bifeng Pan
Charles Askew
Alice Galvin
Selena Heman-Ackah
Yukako Asai
Artur A Indzhykulian
Francine M Jodelka
Michelle L Hastings
Jennifer J Lentz
Luk H Vandenberghe
Jeffrey R Holt
Gwenaëlle S Géléoc
机构：
[1] F.M. Kirby Center for Neurobiology,Department of Otolaryngology
[2] Boston Children's Hospital,Department of Neurobiology
[3] Harvard Medical School,Department of Cell Biology & Anatomy
[4] Harvard Medical School,Department of Otorhinolaryngology & Bio
[5] Chicago Medical School,communications and Neuroscience Center
[6] Rosalind Franklin University of Medicine and Science,Department of Ophthalmology
[7] LSU Health Sciences Center,Department of Neurology
[8] Grousbeck Gene Therapy Center,undefined
[9] Schepens Eye Research Institute and Massachusetts Eye and Ear,undefined
[10] Harvard Medical School,undefined
[11] F.M. Kirby Center for Neurobiology,undefined
[12] Boston Children's Hospital,undefined
[13] Harvard Medical School,undefined
[14] Present addresses: Gene Therapy Center,undefined
[15] University of North Carolina,undefined
[16] Chapel Hill,undefined
[17] North Carolina,undefined
[18] USA (C.A.); MedStar Washington Hospital Center,undefined
[19] Georgetown University Medical Center,undefined
[20] Washington,undefined
[21] DC,undefined
[22] USA (S.H.-A.).,undefined
来源：
Nature Biotechnology | 2017年 / 35卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Gene therapy in the inner ear achieves unprecedented recovery of hearing and balance behavior in Usher syndrome mice.
引用
收藏
页码：264 / 272
页数：8
相关论文
共 50 条
  • [1] Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c
    Pan, Bifeng
    Askew, Charles
    Galvin, Alice
    Heman-Ackah, Selena
    Asai, Yukako
    Indzhykulian, Artur A.
    Jodelka, Francine M.
    Hastings, Michelle L.
    Lentz, Jennifer J.
    Vandenberghe, Luk H.
    Holt, Jeffrey R.
    Geleoc, Gwenaelle S.
    NATURE BIOTECHNOLOGY, 2017, 35 (03) : 264 - +
  • [2] Gene Therapy Restores Auditory and Vestibular Function in a Mouse Model for Usher Syndrome Type 1C
    Askew, Charles
    Pan, Bifeng
    Galvin, Alice
    Heman-Ackah, Selena Selena
    Asai, Yukako
    Indzhykulian, Artur A.
    Jodelka, Francine M.
    Hastings, Michelle L.
    Lentz, Jennifer J.
    Vandenberghe, Luk H.
    Holt, Jeffrey R.
    Geleoc, Gwenaelle G. S.
    MOLECULAR THERAPY, 2017, 25 (05) : 352 - 352
  • [3] Long-Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model
    Du, Weinan
    Huang, Jun
    Zhang, Aizhen
    Zhao, Fangfang
    Chen, Tianwen
    Mcdermott, Quinn M.
    Zheng, Tony
    Wang, Haibo
    Zhang, Rongli
    Zhang, Xiaolin
    Allison, Jerome
    Zhu, Hong
    Zhou, Wu
    Zheng, Qing Yin
    ADVANCED SCIENCE, 2025,
  • [4] Local gene therapy durably restores vestibular function in a mouse model of Usher syndrome type 1G
    Emptoz, Alice
    Michel, Vincent
    Lelli, Andrea
    Akil, Omar
    de Monvel, Jacques Boutet
    Lahlou, Ghizlene
    Meyer, Anais
    Dupont, Typhaine
    Nouaille, Sylvie
    Ey, Elody
    de Barros, Filipa Franca
    Beraneck, Mathieu
    Dulon, Didier
    Hardelin, Jean-Pierre
    Lustig, Lawrence
    Avan, Paul
    Petit, Christine
    Safieddine, Saaid
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (36) : 9695 - 9700
  • [5] Gene Therapy Restores Balance and Auditory Functions in a Mouse Model of Usher Syndrome
    Isgrig, Kevin
    Shteamer, Jack W.
    Belyantseva, Inna A.
    Drummond, Meghan C.
    Fitzgerald, Tracy S.
    Vijayakumar, Sarath
    Jones, Sherri M.
    Griffith, Andrew J.
    Friedman, Thomas B.
    Cunningham, Lisa L.
    Chien, Wade W.
    MOLECULAR THERAPY, 2017, 25 (03) : 780 - 791
  • [6] Therapy Strategies for Usher Syndrome Type 1C in the Retina
    Nagel-Wolfrum, Kerstin
    Baasov, Timor
    Wolfrum, Uwe
    RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY, 2014, 801 : 741 - 747
  • [7] Gene Therapy Restores Balance and Auditory Functions in a Mouse Model of Usher Syndrome (vol 25, pg 780, 2017)
    Isgrig, Kevin
    Shteamer, Jack W.
    Belyantseva, Inna A.
    Drummond, Meghan C.
    Fitzgerald, Tracy S.
    Vijayakumar, Sarath
    Jones, Sherri M.
    Griffith, Andrew J.
    Friedman, Thomas B.
    Cunningham, Lisa L.
    Chien, Wade W.
    MOLECULAR THERAPY, 2022, 30 (02) : 975 - 975
  • [8] A recessive contiguous gene syndrome identifies the type 1C Usher gene.
    Bitner-Glindzicz, M
    Lindley, KJ
    Rutland, P
    Blaydon, D
    Malcolm, S
    Farndon, P
    Dunne, MJ
    Aynsley-Green, A
    Glaser, B
    Hussain, K
    Smith, VV
    Milla, P
    Furth-Lavi, J
    Sowden, J
    Scanlan, MJ
    Liu, XZ
    JOURNAL OF MEDICAL GENETICS, 2000, 37 : S29 - S29
  • [9] Lentiviral gene replacement therapy of retinas in a mouse model for Usher syndrome type 1B
    T Hashimoto
    D Gibbs
    C Lillo
    S M Azarian
    E Legacki
    X-M Zhang
    X-J Yang
    D S Williams
    Gene Therapy, 2007, 14 : 584 - 594
  • [10] Lentiviral gene replacement therapy of retinas in a mouse model for Usher syndrome type 1B
    Hashimoto, T.
    Gibbs, D.
    Lillo, C.
    Azarian, S. M.
    Legacki, E.
    Zhang, X-M
    Yang, X-J
    Williams, D. S.
    GENE THERAPY, 2007, 14 (07) : 584 - 594
12345