Influence of Al3+, Fe3+ and Zn2+ Ions on Phosphorylation of Tubulin and Microtubulo-Associated Proteins of Rat Brain

被引：0
作者：
P. N. Shevtsov
E. F. Shevtsova
O. K. Savushkina
G. Sh. Burbaeva
S. O. Bachurin
机构：
[1] Research Center for Mental Health,Laboratory of Neurochemistry
[2] Russian Academy of Sciences,Laboratory of Biomolecular Screening, Institute of Physiologically Active Compounds
来源：
Bulletin of Experimental Biology and Medicine | 2018年 / 165卷
关键词：
Alzheimer’s disease; microtubules; metals; phosphorylation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Phosphorylation of τ-protein, a component of microtubules in brain neurons, is a key pathomorphological sign of Alzheimer’s disease. The development of this intracellular defect can be promoted by Al3+, Fe3+, and Zn2+ ions. The concentrations of these ions in the brain are considerably elevated in Alzheimer’s disease. We performed a comparative study of phosphorylation of microtubular proteins of rat brain in the presence of Al3+, Fe3+, and Zn2+ ions in concentrations of 10-500 μM and microtubular proteins of brain of patients with Alzheimer’s disease. The most likely candidate for the role of a factor that promotes hyperphosphorylation of τ-protein is Al3+ in concentrations of 250 and 500 μM.
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页码：512 / 515
页数：3
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