Influence of Al3+, Fe3+ and Zn2+ Ions on Phosphorylation of Tubulin and Microtubulo-Associated Proteins of Rat Brain

被引：0

作者：

P. N. Shevtsov

E. F. Shevtsova

O. K. Savushkina

G. Sh. Burbaeva

S. O. Bachurin

机构：

[1] Research Center for Mental Health,Laboratory of Neurochemistry

[2] Russian Academy of Sciences,Laboratory of Biomolecular Screening, Institute of Physiologically Active Compounds

来源：

Bulletin of Experimental Biology and Medicine | 2018年 / 165卷

关键词：

Alzheimer’s disease; microtubules; metals; phosphorylation;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Phosphorylation of τ-protein, a component of microtubules in brain neurons, is a key pathomorphological sign of Alzheimer’s disease. The development of this intracellular defect can be promoted by Al3+, Fe3+, and Zn2+ ions. The concentrations of these ions in the brain are considerably elevated in Alzheimer’s disease. We performed a comparative study of phosphorylation of microtubular proteins of rat brain in the presence of Al3+, Fe3+, and Zn2+ ions in concentrations of 10-500 μM and microtubular proteins of brain of patients with Alzheimer’s disease. The most likely candidate for the role of a factor that promotes hyperphosphorylation of τ-protein is Al3+ in concentrations of 250 and 500 μM.

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页码：512 / 515

页数：3

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[1] Influence of Al3+, Fe3+ and Zn2+ Ions on Phosphorylation of Tubulin and Microtubulo-Associated Proteins of Rat Brain [J].

Shevtsov, P. N. ;

Shevtsova, E. F. ;

Savushkina, O. K. ;

Burbaeva, G. Sh. ;

Bachurin, S. O. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2018, 165 (04) :512-515

[2] Distinct Effects of Zn2+, Cu2+, Fe3+, and Al3+ on Amyloid-β Stability, Oligomerization, and Aggregation [J].

Chen, Wei-Ting ;

Liao, Yi-Hung ;

Yu, Hui-Ming ;

Cheng, Irene H. ;

Chen, Yun-Ru .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (11) :9646-9656

[3] A novel acylhydrazone-based derivative as dual -mode chemosensor for Al3+, Zn2+ and Fe3+ and its applications in cell imaging [J].

Liao, Zhuang ;

Liu, Yang ;

Han, Su-Fang ;

Wang, Dan ;

Zheng, Jian-Quan ;

Zheng, Xiang-Jun ;

Jin, Lin-Pei .

SENSORS AND ACTUATORS B-CHEMICAL, 2017, 244 :914-921

[4] An Indole-based Chromofluorogenic Probe for Detection of Trivalent Al3+, Ga3+, In3+ and Fe3+ Ions [J].

Yadav, Vikas ;

Saini, Saakshi ;

Roy, Partha ;

Layek, Samar ;

Goswami, Tapas ;

Kumar, Sushil .

CHEMPLUSCHEM, 2024, 89 (04)

[5] The design of a simple fluorescent chemosensor for Al3+/Zn2+ via two different approaches [J].

Qin, Jing-can ;

Fan, Long ;

Wang, Bao-dui ;

Yang, Zheng-yin ;

Li, Tian-rong .

ANALYTICAL METHODS, 2015, 7 (02) :716-722

[6] A rhodamine based biocompatible chemosensor for Al3+, Cr3+ and Fe3+ ions: extraordinary fluorescence enhancement and a precursor for future chemosensors [J].

Roy, Ankita ;

Das, Soumi ;

Sacher, Sukriti ;

Mandal, Sushil Kumar ;

Roy, Partha .

DALTON TRANSACTIONS, 2019, 48 (47) :17594-17604

[7] A new multi-analyte fluorogenic sensor for efficient detection of Al3+ and Zn2+ ions based on ESIPT and CHEF features [J].

Patra, Lakshman ;

Das, Sangita ;

Gharami, Saswati ;

Aich, Krishnendu ;

Mondal, Tapan Kumar .

NEW JOURNAL OF CHEMISTRY, 2018, 42 (23) :19076-19082

[8] Tb-MOF: a naked-eye and regenerable fluorescent probe for selective and quantitative detection of Fe3+ and Al3+ ions [J].

Zhang, Mengfei ;

Han, Jing ;

Wu, Haipeng ;

Wei, Qing ;

Xie, Gang ;

Chen, Sanping ;

Gao, Shengli .

RSC ADVANCES, 2016, 6 (97) :94622-94628

[9] Colorimetric detection of Fe3+/2+ and fluorescent detection of Al3+ in aqueous media: applications and DFT calculations [J].

Kim, So Young ;

Lee, Seong Youl ;

Kang, Ji Hye ;

Kim, Min Seon ;

Kim, Ahran ;

Kim, Cheal .

JOURNAL OF COORDINATION CHEMISTRY, 2018, 71 (15) :2401-2414

[10] A differentially selective molecular probe for detection of trivalent ions (Al3+, Cr3+ and Fe3+) upon single excitation in mixed aqueous medium [J].

Paul, Sima ;

Manna, Abhishek ;

Goswami, Shyamaprosad .

DALTON TRANSACTIONS, 2015, 44 (26) :11805-11810