Global and local development of gray and white matter volume in normal children and adolescents

被引:0
作者
Marko Wilke
Ingeborg Krägeloh-Mann
Scott K. Holland
机构
[1] Cincinnati Children’s Hospital Medical Center,Imaging Research Center
[2] University of Tübingen,Department of Pediatric Neurology and Developmental Medicine, Children’s Hospital
来源
Experimental Brain Research | 2007年 / 178卷
关键词
Normal brain development; Brain morphology; Structural magnetic resonance imaging; Voxel-based morphometry; VBM; Gender differences; Normal ageing;
D O I
暂无
中图分类号
学科分类号
摘要
Over the last decade, non-invasive, high-resolution magnetic resonance imaging has allowed investigating normal brain development. However, much is still not known in this context, especially with regard to regional differences in brain morphology between genders. We conducted a large-scale study utilizing fully automated analysis-approaches, using high-resolution MR-imaging data from 200 normal children and aimed at providing reference data for future neuroimaging studies. Global and local aspects of normal development of gray and white matter volume were investigated as a function of age and gender while covarying for known nuisance variables. Global developmental patterns were apparent in both gray and white matter, with gray matter decreasing and white matter increasing significantly with age. Gray matter loss was most pronounced in the parietal lobes and least in the cingulate and in posterior temporal regions. White matter volume gains with age were almost uniform, with an accentuation of the pyramidal tract. Gender influences were detectable for both gray and white matter. Voxel-based analyses confirmed significant differences in brain morphology between genders, like a larger amygdala in boys or a larger caudate in girls. We could demonstrate profound influences of both age and gender on normal brain morphology, confirming and extending earlier studies. The knowledge of such influence allows for the consideration of age- and gender-effects in future pediatric neuroimaging studies and advances our understanding of normal and abnormal brain development.
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页码:296 / 307
页数:11
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