Frequency and determinants for hemorrhagic transformation of posterior cerebral stroke: Posterior ischemic stroke and hemorrhagic transformation

被引：22

作者：

Valentino F. ^{[1
]}

Gentile L. ^{[2
]}

Terruso V. ^{[3
]}

Mastrilli S. ^{[1
]}

Aridon P. ^{[1
]}

Ragonese P. ^{[1
]}

Sarno C. ^{[4
]}

Savettieri G. ^{[1
]}

D'Amelio M. ^{[1
]}

机构：

[1] Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BioNeC), Università degli Studi di Palermo, Via Gaetano La Loggia 1, Palermo

[2] Dipartimento di Neurologia e Psichiatria, Università degli Studi di Roma la Sapienza, Rome

[3] ARNAS Civico, Di Cristina e Benfratelli, Palermo

[4] Azienda Ospedaliera Universitaria Policlinico P. Giaccone, Palermo

来源：

BMC Research Notes | / 10卷 / 1期

关键词：

Epidemiology; Hemorrhagic transformation; Posterior ischemic stroke;

D O I：

10.1186/s13104-017-2889-x

中图分类号：

学科分类号：

摘要：

Background: hemorrhagic transformation is a threatening ischemic stroke complication. Frequency of hemorrhagic transformation differs greatly among studies, and its risk factors have been usually studied in patients with anterior ischemic stroke who received thrombolytic therapy. We evaluated, in a hospital-based series of patients with posterior ischemic stroke not treated with thrombolysis, frequency and risk factors of hemorrhagic transformation. Patients with posterior circulation stroke were seen in our Department during the period January 2004 to December 2009. Demographic and clinical information were collected. We estimated risk for spontaneous hemorrhagic transformation by means of uni- and multivariate logistic regression analyses. Results: 119 consecutive patients were included (73 males, 61.3%). Hemorrhagic transformation was observed in 7 patients (5.9%). Only clinical worsening was significantly associated with hemorrhagic transformation (OR 6.8, 95% CI 1.3-34.5). Conclusions: Our findings indicate that patients with posterior have a low risk of spontaneous hemorrhagic transformation, suggesting that these patients might have greater advantage from intravenous thrombolysis. © 2017 The Author(s).

引用

共 26 条

[1] Balami J.S., Chen R.L., Grunwald I.Q., Buchan A.M., Neurological complications of acute ischaemic stroke, Lancet Neurol., 10, pp. 357-371, (2011)
[2] D'Amelio M., Terruso V., Famoso G., Di Benedetto N., Realmuto S., Valentino F., Ragonese P., Savettieri G., Aridon P., Early and late mortality of spontaneous hemorrhagic transformation of ischemic stroke, J Stroke Cerebrovasc Dis, 23, pp. 649-654, (2014)
[3] Terruso V., D'Amelio M., Di Benedetto N., Lupo I., Saia V., Famoso G., Mazzola M.A., Aridon P., Sarno C., Ragonese P., Savettieri G., Frequency and determinants for hemorrhagic transformation of cerebral infarction, Neuroepidemiology., 33, pp. 261-265, (2009)
[4] D'Amelio M., Terruso V., Famoso G., Ragonese P., Aridon P., Savettieri G., Cholesterol levels and risk of hemorrhagic transformation after acute ischemic stroke, Cerebrovasc Dis., 32, pp. 234-238, (2011)
[5] Markus H.S., Van Der Worp H.B., Rothwell P.M., Posterior circulation ischaemic stroke and transient ischaemic attack: Diagnosis, investigation, and secondary prevention, Lancet Neurol., 12, pp. 989-998, (2013)
[6] Hornig C.R., Buttner T., Hoffmann O., Dorndorf W., Short-term prognosis of vertebro basilar ischemic stroke, Cerebrovasc Dis., 2, pp. 273-281, (1992)
[7] Hatano S., Experience from a multicentre stroke register: A preliminary report, Bull World Health Organ, 54, pp. 541-553, (1976)
[8] Toni D., Fiorelli M., Bastianello S., Sacchetti M.L., Sette G., Argentino C., Montinaro E., Bozzao L., Hemorrhagic transformation of brain infarcts: Predictability in the first 5 hours from stroke onset and influence on clinical outcome, Neurology., 46, pp. 341-345, (1996)
[9] Larrue V., Von K.R., Del Zoppo G., Bluhmki E., Haemorrhagic transformation in acute ischaemic stroke. Potential contributing factors in the European Cooperative Acute Stroke Study, Stroke, 28, pp. 957-960, (1997)
[10] Adams H.P., Bendixen B.H., Kappelle L.J., Biller J., Love B.B., Gordon D.L., Marsh E.E., Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial, Stroke, 24, pp. 35-41, (1993)

← 1 2 3 →