A New Perspective for Parkinson’s Disease: Circadian Rhythm

被引：0
作者：
Siyue Li
Yali Wang
Fen Wang
Li-Fang Hu
Chun-Feng Liu
机构：
[1] The Second Affiliated Hospital of Soochow University,Department of Neurology and Suzhou Clinical Research Center of Neurological Disease
[2] Soochow University,Institutes of Neuroscience
来源：
Neuroscience Bulletin | 2017年 / 33卷
关键词：
Parkinson’s disease; Circadian rhythm; Sleep; Dopamine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Circadian rhythm is manifested by the behavioral and physiological changes from day to night, which is controlled by the pacemaker and its regulator. The former is located at the suprachiasmatic nuclei (SCN) in the anterior hypothalamus, while the latter is composed of clock genes present in all tissues. Circadian desynchronization influences normal patterns of day-night rhythms such as sleep and alertness cycles, rest and activity cycles. Parkinson’s disease (PD) exhibits diurnal fluctuations. Circadian dysfunction has been observed in PD patients and animal models, which may result in negative consequences to the homeostasis and even exacerbate the disease progression. Therefore, circadian therapies, including light stimulation, physical activity, dietary and social schedules, may be helpful for PD patients. However, the cellular and molecular mechanisms that underlie the circadian dysfunction in PD remain elusive. Further research on circadian patterns is needed. This article summarizes the existing research on the circadian rhythms in PD, focusing on the clinical symptom variations, molecular changes, as well as the available treatment options.
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页码：62 / 72
页数：10
相关论文
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[1]  
Pringsheim T(2014)The prevalence of Parkinson’s disease: a systematic review and meta-analysis Mov Disord 29 1583-1590
[2]  
Jette N(2010)REM sleep behavior disorder: Updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions Ann N Y Acad Sci 1184 15-54
[3]  
Frolkis A(2003)Staging of brain pathology related to sporadic Parkinson’s disease Neurobiol Aging 24 197-211
[4]  
Steeves TD(2005)Regulation of dopaminergic transmission and cocaine reward by the Clock gene Proc Natl Acad Sci U S A 102 9377-9381
[5]  
Boeve BF(1997)Structure and organization of the gene encoding human dopamine transporter Gene 195 11-18
[6]  
Braak H(2010)Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior Biol Psychiatry 68 503-511
[7]  
Del Tredici K(2009)Dopamine receptor-mediated regulation of neuronal “clock” gene expression Neuroscience 158 537-544
[8]  
Rub U(2006)Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1 Proc Natl Acad Sci U S A 103 6386-6391
[9]  
de Vos RA(2010)Endogenous dopamine regulates the rhythm of expression of the clock protein PER2 in the rat dorsal striatum via daily activation of D2 dopamine receptors J Neurosci 30 14046-14058
[10]  
Jansen Steur EN(2006)Expression of clock and clock-driven genes in the rat suprachiasmatic nucleus during late fetal and early postnatal development J Biol Rhythms 21 140-148
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