Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058

被引：0
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作者：
Toshihiko Nogawa
Naoki Kato
Takeshi Shimizu
Akiko Okano
Yushi Futamura
Shunji Takahashi
Hiroyuki Osada
机构：
[1] RIKEN Center for Sustainable Resource Science,
[2] Chemical Biology Research Group,undefined
[3] RIKEN Center for Sustainable Resource Science,undefined
[4] Natural Product Biosynthesis Research Unit,undefined
来源：
The Journal of Antibiotics | 2018年 / 71卷
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摘要：
Two new decaline metabolites, wakodecalines A and B, were isolated from a fungus, Pyrenochaetopsis sp. RK10-F058, by screening for structurally unique metabolites using LC/MS analysis. Their structures were determined on the basis of NMR and mass spectrometric measurements. The absolute structures were confirmed by a combination of chemical methods including chemical degradation, a modified Mosher’s method and Marfey’s method, and comparison of the experimental electronic CD (ECD) spectrum with calculated one. Both compounds had a cyclopentanone-fused decaline skeleton and an N-methylated amino acid moiety derived from a serine. They showed moderate antimalarial activity against the Plasmodium falciparum 3D7 strain.
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页码：123 / 128
页数：5
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