Synthesis of new 1H-1,2,4-triazolylcoumarins and their antitumor and anti-HIV activities

被引：0
作者：
Al-Soud Y.A. [1 ]
Al-Masoudi I.A. [2 ]
Saeed B. [3 ]
Beifuß U. [4 ]
Al-Masoudi N.A. [5 ]
机构：
[1] Department of Chemistry, College of Science, University of Al Al-Bayt, Al-Mafraq
[2] College of Veterinary, University of Basrah, Basrah
[3] Department of Chemistry, College of Education, University of Basrah, Basrah
[4] Fakultät für Chemie, Universität Hohenheim
来源：
Chemistry of Heterocyclic Compounds | 2006年 / 42卷 / 5期
关键词：
1,2,4-triazoles; Antitumor activity; Antiviral activity; Coumarin; Cycloaddition;
D O I：
10.1007/s10593-006-0130-2
中图分类号：
学科分类号：
摘要：
A variety of 7-[(1,5-dialkyl-1H-1,2,4-triazolyl)methoxy(and methyl)]coumarins were synthesized from cycloaddition of 2-(2H-benzopyran-7- yloxy)acetonitrile and 2-(5-methoxy-4-methyl-2H-benzopyran-7-yloxy)acetonitrile, respectively, with various reactive cumulene >C=N+=N- intermediates via spontaneous rearrangements. The anticancer (breast, lung, CNS cancers) and antiviral (HIV-1, HIV-2) properties of some compounds were investigated in vitro. 5-Methoxy-4-methyl-7-[(6,7,8,9-tetrahydro-5H-[1,2,4] triazolo[1,5-a]azepin-2-yl)methyl]coumarin showed some inhibition of HIV-1. ©2006 Springer Science+Business Media, Inc.
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页码：583 / 590
页数：7
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