Sodium channel blockers for the treatment of neuropathic pain

被引：0
|
作者：
Anindya Bhattacharya
Alan D. Wickenden
Sandra R. Chaplan
机构：
[1] Johnson & Johnson Pharmaceutical Research & Development,Pain & Related Disorders Team
[2] LLC,undefined
来源：
Neurotherapeutics | 2009年 / 6卷
关键词：
Sodium channel; subtype; selectivity; neuropathic pain; drug discovery;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Drugs that block voltage-gated sodium channels are efficacious in the management of neuropathic pain. Accordingly, this class of ion channels has been a major focus of analgesic research both in academia and in the pharmaceutical/biotechnology industry. In this article, we review the history of the use of sodium channel blockers, describe the current status of sodium channel drug discovery, highlight the challenges and hurdles to attain sodium channel subtype selectivity, and review the potential usefulness of selective sodium channel blockers in neuropathic pain.
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页码：663 / 678
页数：15
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