Cyanide Reaction with Ninhydrin: Elucidation of Reaction and Interference Mechanisms

被引：0

作者：

Gabi Drochioiu

Ionel Mangalagiu

Ecaterina Avram

Karin Popa

Alin Constantin Dirtu

Ioan Druta

机构：

[1] Al. I. Cuza University of Iasi,Organic Chemistry and Biochemistry Department

[2] Petru Poni Institute of Macromolecular Chemistry,Analytical Chemistry Department

[3] Al. I. Cuza University of Iasi,undefined

来源：

Analytical Sciences | 2004年 / 20卷

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摘要：

A new sensitive spectrophotometric method has recently been developed for the trace determination of cyanide with ninhydrin. Cyanide ion was supposed to act as a specific base catalyst. Nevertheless, this paper demonstrates that the reported assay is based on a novel reaction of cyanide with 2,2-dihydroxy-1,3-indanedione, which affords purple or blue colored salts of 2-cyano-1,2,3-trihydroxy-2H indene. Hydrindantin is merely an intermediary of the reaction. The formation of a stable and isolable ninhydrin-cyanide compound has been confirmed by its preparation in crystalline form. Also, it is thoroughly characterized by elemental as well as MS, IR, UV/VIS and 1H NMR analyses. The Ruhemann’s sequence of reactions of cyanide with ninhydrin has been reconsidered and an adequate mechanism of the reaction is proposed. As a consequence, the interference of oxidizers as well as copper, silver and mercury ions with the cyanide determination has been elucidated.

引用

页码：1443 / 1447

页数：4

共 40 条

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