Breast cancer survival in African-American women by hormone receptor subtypes

被引：18

作者：

Akinyemiju, Tomi ^{[1
]}

Moore, Justin Xavier ^{[1
,2
]}

Altekruse, Sean F. ^{[3
]}

机构：

[1] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Dept Emergency Med, Sch Med, Birmingham, AL 35294 USA

[3] NCI, Canc Stat Branch, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2015年 / 153卷 / 01期

关键词：

Breast cancer; Hormone receptor subtype; Triple negative; African Americans; Survival;

D O I：

10.1007/s10549-015-3528-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer accounts for over 200,000 annual cases among women in the United States, and is the second leading cause of cancer-related deaths. However, few studies have investigated the association between breast cancer subtype and survival among African-American women. We analyzed cancer-related deaths among African-American women using data obtained from the SEER database linked to the 2000 U.S. census data. We examined distribution of baseline socio-demographic and clinical characteristics by breast cancer subtypes and used Cox proportional hazard models to determine associations between breast cancer subtypes and cancer-related mortality, adjusting for age, socio-economic status, stage at diagnosis, and treatment. Among 19,836 female breast cancer cases, 54.4 % were diagnosed with the HER2-/HR+ subtype, with the majority of those cases occurring among women ages 55 and older. However, after adjusting for age, stage, and treatment type (surgery, radiation, or no radiation and/or cancer-directed surgery), TNBC (HR 2.34; 95 % CI 1.95-2.81) and HER2+/HR- (HR 1.39, 95 % CI 1.08-1.79) cases had significantly higher hazards of cancer-related deaths compared with HER2+/HR+ cases. Adjusting for socio-economic status did not significantly alter these associations. African-American women with TNBC were more likely to have a cancer-related death than African-American women with other breast cancer subtypes. This association remained after adjustments for age, stage, treatment, and socio-economic status. Further studies are needed to identify subtype-specific risk and prognostic factors aimed at better informing prevention efforts for all women.

引用

页码：211 / 218

页数：8

共 56 条

[1]

DeSantis C., Ma J., Bryan L., Jemal A., Breast cancer statistics, 2013, CA Cancer J Clin, 64, 1, pp. 52-62, (2014)

[2]

Howlander N., Noone A.M., Krapcho M., Garshell j M.D., Altekruse S.F., Kosary C.L., Yu M., Seer Cancer Statistics Review, 1975–2012, (2015)

[3]

Smigal C., Jemal A., Ward E., Cokkinides V., Smith R., Howe H.L., Thun M., Trends in breast cancer by race and ethnicity: update 2006, CA Cancer J Clin, 56, 3, pp. 168-183, (2006)

[4]

Weir H.K., Thun M.J., Hankey B.F., Ries L.A., Howe H.L., Wingo P.A., Jemal A., Ward E., Anderson R.N., Edwards B.K., Annual report to the nation on the status of cancer, 1975–2000, featuring the uses of surveillance data for cancer prevention and control, J Natl Cancer Inst, 95, 17, pp. 1276-1299, (2003)

[5]

Keegan T.H., Kurian A.W., Gali K., Tao L., Lichtensztajn D.Y., Hershman D.L., Habel L.A., Caan B.J., Gomez S.L., Racial/ethnic and socioeconomic differences in short-term breast cancer survival among women in an integrated health system, Am J Public Health, 105, 5, pp. 938-946, (2015)

[6]

Newman L.A., Breast cancer disparities: high-risk breast cancer and African ancestry, Surg Oncol Clin N Am, 23, 3, pp. 579-592, (2014)

[7]

Tammemagi C.M., Nerenz D., Neslund-Dudas C., Feldkamp C., Nathanson D., Comorbidity and survival disparities among black and white patients with breast cancer, JAMA, 294, 14, pp. 1765-1772, (2005)

[8]

Akinyemiju T.F., Soliman A.S., Johnson N.J., Altekruse S.F., Welch K., Banerjee M., Schwartz K., Merajver S., Individual and neighborhood socioeconomic status and healthcare resources in relation to black-white breast cancer survival disparities, J Cancer Epidemiol, 2013, (2013)

[9]

Akinyemiju T.F., Soliman A.S., Copeland G., Banerjee M., Schwartz K., Merajver S.D., Trends in breast cancer stage and mortality in Michigan (1992–2009) by race, socioeconomic status, and area healthcare resources, PLoS One, 8, 4, (2013)

[10]

Joslyn S.A., Foote M.L., Nasseri K., Coughlin S.S., Howe H.L., Racial and ethnic disparities in breast cancer rates by age: NAACCR Breast Cancer Project, Breast Cancer Res Treat, 92, 2, pp. 97-105, (2005)

← 1 2 3 4 5 6 →