CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production

被引：0

作者：

Vishal Khairnar

Vikas Duhan

Sathish Kumar Maney

Nadine Honke

Namir Shaabani

Aleksandra A. Pandyra

Marc Seifert

Vitaly Pozdeev

Haifeng C. Xu

Piyush Sharma

Fabian Baldin

Florian Marquardsen

Katja Merches

Elisabeth Lang

Carsten Kirschning

Astrid M. Westendorf

Dieter Häussinger

Florian Lang

Ulf Dittmer

Ralf Küppers

Mike Recher

Cornelia Hardt

Inka Scheffrahn

Nicole Beauchemin

Joachim R. Göthert

Bernhard B. Singer

Philipp A. Lang

Karl S. Lang

机构：

[1] Institute of Immunology,Department of Biomedicine

[2] Medical Faculty,Department of Physiology I

[3] University of Duisburg-Essen,Departments of Biochemistry

[4] Clinic of Gastroenterology,Department of Hematology

[5] Hepatology and Infectious Diseases,Department of Molecular Medicine II

[6] Heinrich-Heine-University,undefined

[7] Institute of Cell Biology (Cancer Research),undefined

[8] University of Duisburg-Essen,undefined

[9] Clinic for Primary Immunodeficiency,undefined

[10] Medical Outpatient Unit and Immunodeficiency Laboratory,undefined

[11] University Hospital,undefined

[12] University of Tuebingen,undefined

[13] Institute of Medical Microbiology,undefined

[14] Faculty of Medicine,undefined

[15] University Hospital Essen,undefined

[16] Institute of Virology,undefined

[17] University of Duisburg-Essen,undefined

[18] Clinic of Gastroenterology and Hepatology,undefined

[19] University of Duisburg-Essen,undefined

[20] Rosalind and Morris Goodman Cancer Centre,undefined

[21] Medicine and Oncology,undefined

[22] McIntyre Medical Science Building,undefined

[23] West German Cancer Center (WTZ),undefined

[24] University Hospital Essen,undefined

[25] Institute of Anatomy,undefined

[26] Medical Faculty,undefined

[27] University of Duisburg-Essen,undefined

[28] Heinrich Heine University Düsseldorf,undefined

来源：

Nature Communications | / 6卷

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摘要：

B cells are essential for antiviral immune defence because they produce neutralizing antibodies, present antigen and maintain the lymphoid architecture. Here we show that intrinsic signalling of CEACAM1 is essential for generating efficient B-cell responses. Although CEACAM1 exerts limited influence on the proliferation of B cells, expression of CEACAM1 induces survival of proliferating B cells via the BTK/Syk/NF-κB-axis. The absence of this signalling cascade in naive Ceacam1−/− mice limits the survival of B cells. During systemic infection with cytopathic vesicular stomatitis virus, Ceacam1−/− mice can barely induce neutralizing antibody responses and die early after infection. We find, therefore, that CEACAM1 is a crucial regulator of B-cell survival, influencing B-cell numbers and protective antiviral antibody responses.

引用

共 108 条

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