CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production

被引：0
作者：
Vishal Khairnar
Vikas Duhan
Sathish Kumar Maney
Nadine Honke
Namir Shaabani
Aleksandra A. Pandyra
Marc Seifert
Vitaly Pozdeev
Haifeng C. Xu
Piyush Sharma
Fabian Baldin
Florian Marquardsen
Katja Merches
Elisabeth Lang
Carsten Kirschning
Astrid M. Westendorf
Dieter Häussinger
Florian Lang
Ulf Dittmer
Ralf Küppers
Mike Recher
Cornelia Hardt
Inka Scheffrahn
Nicole Beauchemin
Joachim R. Göthert
Bernhard B. Singer
Philipp A. Lang
Karl S. Lang
机构：
[1] Institute of Immunology,Department of Biomedicine
[2] Medical Faculty,Department of Physiology I
[3] University of Duisburg-Essen,Departments of Biochemistry
[4] Clinic of Gastroenterology,Department of Hematology
[5] Hepatology and Infectious Diseases,Department of Molecular Medicine II
[6] Heinrich-Heine-University,undefined
[7] Institute of Cell Biology (Cancer Research),undefined
[8] University of Duisburg-Essen,undefined
[9] Clinic for Primary Immunodeficiency,undefined
[10] Medical Outpatient Unit and Immunodeficiency Laboratory,undefined
[11] University Hospital,undefined
[12] University of Tuebingen,undefined
[13] Institute of Medical Microbiology,undefined
[14] Faculty of Medicine,undefined
[15] University Hospital Essen,undefined
[16] Institute of Virology,undefined
[17] University of Duisburg-Essen,undefined
[18] Clinic of Gastroenterology and Hepatology,undefined
[19] University of Duisburg-Essen,undefined
[20] Rosalind and Morris Goodman Cancer Centre,undefined
[21] Medicine and Oncology,undefined
[22] McIntyre Medical Science Building,undefined
[23] West German Cancer Center (WTZ),undefined
[24] University Hospital Essen,undefined
[25] Institute of Anatomy,undefined
[26] Medical Faculty,undefined
[27] University of Duisburg-Essen,undefined
[28] Heinrich Heine University Düsseldorf,undefined
来源：
Nature Communications | / 6卷
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摘要：
B cells are essential for antiviral immune defence because they produce neutralizing antibodies, present antigen and maintain the lymphoid architecture. Here we show that intrinsic signalling of CEACAM1 is essential for generating efficient B-cell responses. Although CEACAM1 exerts limited influence on the proliferation of B cells, expression of CEACAM1 induces survival of proliferating B cells via the BTK/Syk/NF-κB-axis. The absence of this signalling cascade in naive Ceacam1−/− mice limits the survival of B cells. During systemic infection with cytopathic vesicular stomatitis virus, Ceacam1−/− mice can barely induce neutralizing antibody responses and die early after infection. We find, therefore, that CEACAM1 is a crucial regulator of B-cell survival, influencing B-cell numbers and protective antiviral antibody responses.
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