A prevalence study of typhoid fever and convalescent phase asymptomatic typhoid carriers among the schoolchildren in the northern part of Tamil Nadu

被引：4

作者：

Sivaji I. ^{[1
]}

Duraisamy S. ^{[1
]}

Balakrishnan S. ^{[1
]}

Periasamy S. ^{[2
]}

机构：

[1] Department of Biotechnology, Muthayammal College of Arts and Science, Rasipuram, 637 408, Tamil Nadu

[2] Center for Immunology and Microbial Disease, Albany Medical College, Albany, 12208-3479, NY

来源：

Journal of Public Health | 2015年 / 23卷 / 6期

关键词：

Children; Convalescent typhoid carriers; S. Typhi serovars; Typhoid fever;

D O I：

10.1007/s10389-015-0655-x

中图分类号：

学科分类号：

摘要：

Aim: This study reports, for the first time, the prevalence of typhoid fever and convalescent phase asymptomatic typhoid carriers among the schoolchildren in Vellore district of Tamil Nadu state in India. Subjects and methods: Blood and stool samples (n = 500) were collected from the schoolchildren, who were admitted to District Government hospitals for treatment of typhoid fever or other enteric disorders. Early morning stool and blood samples (n = 700) were collected from the schoolchildren, who had the previous history of typhoid fever. The blood and stool samples were subjected to immunological and bacteriological examination to confirm the cases of typhoid fever and typhoid carriers. Further, S. Typhi isolates from the typhoid patients and asymptomatic carriers were serogrouped by standard protocols at WHO Reference laboratory for Salmonella typing in India. Results: A total of 360/500 (72%) children were positive for typhoid fever; while a total of 147/700 (21%) children were confirmed as convalescent phase asymptomatic typhoid carriers. All the S. Typhi isolates obtained from children positive from typhoid fever or typhoid carriers in this region were found to be serovars 9, 12, Vi: d and 4, 12: i: 1, 2. Conclusion: This study highlights the prevalence of typhoid fever among the schoolchildren and a possible role of convalescent phase asymptomatic typhoid carriers as a risk factor for the spread of infection in this locality. © 2015, Springer-Verlag Berlin Heidelberg.

引用

页码：373 / 378

页数：5

共 23 条

[11]

Prescott L.M., Harley J.P., Klein D.A., Microbiology, pp. 889-984, (2008)

[12]

Prouty A.M., Schwesinger W.H., Gunn J.S., Bio film formation and interaction with the surfaces of gallstones by Salmonella species, Infect Immun, 70, pp. 2640-2649, (2002)

[13]

Rajasekarapandian M., Senthilkumar B., Immunology and immunotechnology, 1st edn, Panima, (2007)

[14]

Reddy S., Rangaiah J., Addiman S., Wareham D., Wilson P., Sefton A., Epidemiology, antibiotic resistance trends and the cost of enteric fever in East London, 2005–2010, Travel Med Infect Dis, (2011)

[15]

Salih H., Mustafa A., Serife A., Mehmet F.G., Ibrahim H.T., Mark L., Risk factors for enteric perforation in patients with typhoid fever, Am J Epidemiol, (2004)

[16]

Senthilkumar B., Prabakaran G., Multidrug resistant S. typhi in asymptomatic typhoid carriers among food handlers in Namakkal District Tamil Nadu, Indian J Med Microbiol, 23, 2, pp. 92-94, (2005)

[17]

Senthilkumar B., Senbagam D., Rajasekarapandian M., An epidemiological surveillance of asymptomatic typhoid carriers associated in respect to socioeconomic status in India, J Pub Health, (2012)

[18]

Senthilkumar B., Sivakumar P., Madhanraj R., Senbagam D., Illakia S., A comparative analysis of TLR5 polymorphism and clinical parameters in typhoid patients and asymptomatic typhoid carriers, J Pub Health, (2014)

[19]

Sinha A., Sazawal S., Kumar R., Sood S., Reddaiah V.P., Singh B., Rao M., Naficy A., Clemens J.D., Bhan M.K., Typhoid fever in children less than 5 years, Lancet, 354, 9180, pp. 734-737, (1999)

[20]

Walsh A.L., Phiri A.J., Graham S.M., Bacteremia in febrile Malawian children: clinical and microbiologic features, Pediatr Infect Dis J, 19, pp. 312-318, (2000)

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