Neuroendocrine carcinoma of the pancreas with similar genetic alterations to invasive ductal adenocarcinoma

被引：22

作者：

Kimura T. ^{[1
]}

Miyamoto H. ^{[1
]}

Fukuya A. ^{[1
]}

Kitamura S. ^{[1
]}

Okamoto K. ^{[1
]}

Kimura M. ^{[1
]}

Muguruma N. ^{[1
]}

Ikemoto T. ^{[2
]}

Shimada M. ^{[2
]}

Yoneda A. ^{[3
]}

Bando Y. ^{[3
]}

Takishita M. ^{[4
]}

Takayama T. ^{[1
]}

机构：

[1] Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15, Kuramoto-cho, Tokushima

[2] Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima

[3] Division of Pathology, Tokushima University Hospital, Tokushima

[4] Anan Kyoei Hospital, Tokushima

来源：

Clinical Journal of Gastroenterology | 2016年 / 9卷 / 4期

关键词：

KRAS; Neuroendocrine carcinoma; p53; Pancreatic cancer; SMAD4;

D O I：

10.1007/s12328-016-0655-6

中图分类号：

学科分类号：

摘要：

Neuroendocrine carcinoma (NEC) of the pancreas is very rare, and its origin is not fully elucidated. Here, we present a case of a small-size NEC of the pancreas that is genetically similar to invasive ductal adenocarcinoma (IDA). A 65-year-old man was referred to our hospital due to obstructive jaundice and found to have a 12-mm solid tumor in the pancreas head. The tumor exhibited low vascularity on enhanced computed tomography, and endoscopic retrograde pancreatographic imaging revealed an irregular obstruction in a branch duct of the pancreas. The patient was thereby diagnosed with a pancreatic ductal cancer, and stomach-preserving pancreaticoduodenectomy with regional lymph node resection was performed. Histochemical analysis of the resected tumor showed that the neoplastic cells with scanty cytoplasm and hyperchromatic nuclei strongly expressed chromogranin A and synaptophysin. The Ki-67 index was 40 % in the most proliferative tumor regions, and the tumor was diagnosed as a NEC of the pancreas. However, in the analysis of genetic alterations of the tumor tissue, the neoplastic cells showed altered KRAS, TP53, and SMAD4/DPC4, suggesting that the NEC in our case is genetically related to IDA. Our data suggest that poorly differentiated IDAs may transform into NECs. © 2016, Japanese Society of Gastroenterology.

引用

页码：261 / 265

页数：4

共 14 条

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