Current Problems of Synaptic Plasticity

被引：0

作者：

Skrebitsky V.G. ^{[1
]}

Sharonova I.N. ^{[1
]}

机构：

[1] Research Center of Neurology, Moscow

来源：

Human Physiology | 2022年 / 48卷 / 8期

关键词：

disinhibition; Hebbian synapses; long-term potentiation; neuropeptides; nootropics; synaptic plasticity;

D O I：

10.1134/S0362119722080059

中图分类号：

学科分类号：

摘要：

Abstract: The present review focuses on the results of modern studies confirming the last century’s ideas about the effect of neuron discharge on the effectiveness of its synaptic inputs. This concept is being developed now at the receptor, channel, and intracellular levels, which allows us to reveal the special role of calcium ions in the activation of a number of cascades leading to transient or long-lasting changes in synaptic transmission. An important role of various physiologically active compounds that affect synaptic plasticity and, through it, the cognitive processes in humans is emphasized, which has not only fundamental, but also applied significance. Cellular and receptor targets of nootropic drugs aimed at the correction of various types of cognitive impairment are considered in detail. © 2022, Pleiades Publishing, Inc.

引用

页码：919 / 927

页数：8

共 71 条

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