Hypoxia inducible factor-1α correlates with VEGF-C expression and lymphangiogenesis in breast cancer

被引：0
作者：
Sebastian F. Schoppmann
Alexandra Fenzl
Monika Schindl
Thomas Bachleitner-Hofmann
Katalin Nagy
Michael Gnant
Reinhard Horvat
Raimund Jakesz
Peter Birner
机构：
[1] University of Vienna,Department of Surgery
[2] University of Vienna,Clinical Institute of Pathology
[3] University of Vienna,Department of Surgery
来源：
Breast Cancer Research and Treatment | 2006年 / 99卷
关键词：
lymphangiogenesis; lymphovascular invasion; prognosis; metastasis; VEGF-C; HIF-1α;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The transcription factor Hypoxia inducible factor-1α (HIF-1α) plays a crucial role in tumor progression by regulating angiogenesis, cell survival and drug resistance. HIF-1α is also implicated in biological functions under normoxic conditions and recent data provide evidence for a possible role in tumor lymphangiogenesis by regulating the lymphatic vascular endothelial growth factor-C (VEGF-C). In breast cancer, lymphatic vessel invasion (LVI) by tumor cells and subsequent metastasis to axillary lymph nodes is a critical point in progression of the disease with severe therapeutical and prognostic implications. Aim of this study is to investigate the role of HIF-1α in VEGF-C expression, lymphangiogenesis, and LVI in lymph node positive breast cancer.
引用
收藏
页码：135 / 141
页数：6
相关论文
共 250 条
  • [1] Semenza GL(2000)HIF-1 and human disease: one highly involved factor Genes Dev 14 1983-1991
  • [2] Wang GL(1995)Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension Proc Natl Acad Sci USA 92 5510-5514
  • [3] Jiang BH(1996)Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension Am J Physiol 271 C1172-C1180
  • [4] Rue EA(1992)Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis Nature 359 843-845
  • [5] Semenza GL(2001)Molecular mechanisms of blood vessel growth Cardiovasc Res 49 507-521
  • [6] Jiang BH(2002)Hypoxia up-regulates mouse vascular endothelial growth factor D promoter activity in rat pulmonary microvascular smooth-muscle cells Chest 121 82S-83S
  • [7] Semenza GL(2004)Expression of vascular endothelial growth factor D is associated with hypoxia inducible factor (HIF-1alpha) and the HIF-1alpha target gene DEC1, but not lymph node metastasis in primary human breast carcinomas J Clin Pathol 57 829-834
  • [8] Bauer C(2005)Correlation of hypoxia inducible factor-1alpha with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer Exp Mol Pathol 78 123-130
  • [9] Marti HH(2004)Differential activation of vascular genes by hypoxia in primary endothelial cells Exp Cell Res 299 476-485
  • [10] Shweiki D(2003)Significant increase in breast conservation in 16 years of trials conducted by the Austrian Breast & Colorectal Cancer Study Group Ann Surg 237 556-564
12345678910