A novel peptide design aids in the expression and its simplified process of manufacturing of Insulin Glargine in Pichia pastoris

被引：0

作者：

Partha Hazra

Suma Sreenivas

Krishnamurthy Venkatesan

Mukesh B. Patale

Amarnath Chatterjee

N. Ramprabu

Ajamoddin M. Shaikh

Mutyalasetty Kusumanchi

机构：

[1] Science and Technology Innovation Center (SNTI),Biocon Biologics Limited (BBL)

[2] Syngene International Limited (Biocon Group of companies),undefined

来源：

Applied Microbiology and Biotechnology | 2021年 / 105卷

关键词：

Insulin glargine; Single-chain precursor processing; Downstream processing; Comparative physicochemical characterization of insulin glargine;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

页码：3061 / 3074

页数：13

共 172 条

[1]

Bretthauer RK(1999)Glycosylation of Biotechnol Appl Biochem 30 193-200

[2]

Castellino FJ(2005)-derived proteins Biophys J 89 3424-3433

[3]

Bromberg L(2017)Insulin particle formation in supersaturated aqueous solutions of poly(ethylene glycol) BioPharm Int 30 6-3359

[4]

Rashba-Step J(1974)Kinetic and Structural Differentiation of Trypsin from Different Origins Biochemistry 13 3350-64

[5]

Scott T(2011)Determination of the helix and beta form of proteins in aqueous solution by circular dichroism Drug Discov Today 16 58-52

[6]

Buddha M(2000)Characterization of protein therapeutics by mass spectrometry: recent developments and future directions Mol Biotechnol 16 23-286

[7]

Hazra P(2008)Recombinant protein expression in J Chromatogr A 1177 282-1405

[8]

Ur K(1985)Process and purification for manufacture of a modified insulin intended for oral delivery J Clin Invest 76 1398-171

[9]

NNP K(2018)Biochemical and clinical implications of proinsulin conversion intermediates BMJ Glob Health 3 164-1789

[10]

Aithal M(2013)Production costs and potential prices for biosimilars of human insulin and insulin analogues Protein Expr Purif 88 31-1499