Electrical activity of the neocortex in adult rats after prenatal hypoxia and in epilepsy model

被引：0

作者：

D. S. Kalinina

A. B. Vol’nova

O. S. Alekseeva

I. A. Zhuravin

机构：

[1] Russian Academy of Sciences,Sechenov Institute of Evolutionary Physiology and Biochemistry

[2] St. Petersburg State University,St. Petersburg State Pediatric Medical University

[3] Ministry of Health of the Russian Federation,undefined

来源：

Journal of Evolutionary Biochemistry and Physiology | 2016年 / 52卷

关键词：

4-aminopyridine; spectral power; ECoG; prenatal hypoxic stress;

D O I：

暂无

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学科分类号：

摘要：

Changes in electrical activity of the neocortex after prenatal hypoxia (day 14 of embryogenesis, E14, 7% O2 for 3 h) and intracortical microinjection of epileptogenic 4-aminopyridine (4-AP) were studied in adult (3-month-old) rats. The frequency–time parameters of electrocorticogram (ECoG) were analyzed during sleep and wakefulness as well as in a model of 4-AP-induced spike-wave discharge (SWD) epileptiform activity. The results showed that in rats exposed to prenatal hypoxia the theta rhythm had a lower frequency while sleep spindles displayed a lower spectral power in the low-frequency range as compared to the control group. In rats with prenatal pathology, there was revealed a delayed onset of epileptiform activity and a shifted frequency distribution of the SWD spectral power induced by 4-AP.

引用

页码：352 / 358

页数：6