Genetic susceptibility to hereditary non-medullary thyroid cancer

被引：0
作者：
Tina Kamani
Parsa Charkhchi
Afshan Zahedi
Mohammad R. Akbari
机构：
[1] University of Toronto,Women’s College Research Institute
[2] University of Toronto,Institute of Medical Science, Faculty of Medicine
[3] University of Toronto,Dalla Lana School of Public Health
来源：
Hereditary Cancer in Clinical Practice | / 20卷
关键词：
Thyroid cancer; Familial non-medullary thyroid cancer; Germline mutations;
D O I：
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学科分类号：
摘要：
Non-medullary thyroid cancer (NMTC) is the most common type of thyroid cancer. With the increasing incidence of NMTC in recent years, the familial form of the disease has also become more common than previously reported, accounting for 5–15% of NMTC cases. Familial NMTC is further classified as non-syndromic and the less common syndromic FNMTC. Although syndromic NMTC has well-known genetic risk factors, the gene(s) responsible for the vast majority of non-syndromic FNMTC cases are yet to be identified. To date, several candidate genes have been identified as susceptibility genes in hereditary NMTC. This review summarizes genetic predisposition to non-medullary thyroid cancer and expands on the role of genetic variants in thyroid cancer tumorigenesis and the level of penetrance of NMTC-susceptibility genes.
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