Aspirin inhibits proliferation of gemcitabine-resistant human pancreatic cancer cells and augments gemcitabine-induced cytotoxicity

[1] Lowenfels AB(2004)Epidemiology and prevention of pancreatic cancer Jpn J Clin Oncol 34 238-44

[2] Maisonneuve P(2003)Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death Oncogene 22 3243-51

[3] Arlt A(2004)Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis Cancer 101 2351-62

[4] Gehrz A(2008)Preclinical toxicology (subacute and acute) and efficacy of a new squalenoyl gemcitabine anticancer nanomedicine J Pharmacol Exp Ther 325 484-90

[5] Muerkoster S(2007)Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells Blood 110 735-42

[6] Vorndamm J(2005)Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells Cancer Res 65 2076-81

[7] Kruse ML(2005)The role of aspirin-triggered lipoxins in the mechanism of action of aspirin Prostaglandins Leukot Essent Fatty Acids 73 203-10

[8] Folsch UR(2003)Reduction of beta-catenin/T-cell transcription factor signaling by aspirin and indomethacin is caused by an increased stabilization of phosphorylated beta-catenin Mol Cancer Ther 2 509-16

[9] Li L(2005)Nuclear factor kappa B activation is a potential target for preventing pancreatic carcinoma by aspirin Cancer 103 2485-90

[10] Aggarwal BB(2007)K-ras oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment Cancer Sci 98 1128-36

[1] Lowenfels AB(2004)Epidemiology and prevention of pancreatic cancer Jpn J Clin Oncol 34 238-44

[2] Maisonneuve P(2003)Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death Oncogene 22 3243-51

[3] Arlt A(2004)Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis Cancer 101 2351-62

[4] Gehrz A(2008)Preclinical toxicology (subacute and acute) and efficacy of a new squalenoyl gemcitabine anticancer nanomedicine J Pharmacol Exp Ther 325 484-90

[5] Muerkoster S(2007)Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells Blood 110 735-42

[6] Vorndamm J(2005)Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells Cancer Res 65 2076-81

[7] Kruse ML(2005)The role of aspirin-triggered lipoxins in the mechanism of action of aspirin Prostaglandins Leukot Essent Fatty Acids 73 203-10

[8] Folsch UR(2003)Reduction of beta-catenin/T-cell transcription factor signaling by aspirin and indomethacin is caused by an increased stabilization of phosphorylated beta-catenin Mol Cancer Ther 2 509-16

[9] Li L(2005)Nuclear factor kappa B activation is a potential target for preventing pancreatic carcinoma by aspirin Cancer 103 2485-90

[10] Aggarwal BB(2007)K-ras oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment Cancer Sci 98 1128-36