Biomarkers to Identify the Pathological Basis for Frontotemporal Lobar Degeneration

被引：0
作者：
Murray Grossman
机构：
[1] University of Pennsylvania School of Medicine,Department of Neurology–2 Gibson
来源：
Journal of Molecular Neuroscience | 2011年 / 45卷
关键词：
Frontotemporal lobar degeneration; Biomarker; Cerebrospinal fluid; Neuroimaging;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recent findings assessing the utility of biomarkers are reviewed that help identify the basis for disease in patients with frontotemporal lobar degeneration (FTLD) spectrum pathology. Biofluid studies identify about 15% of patients with FTLD due to a genetic mutation that is associated with the specific histopathologic features of TDP-43 or a tauopathy. Other genetically based risk factors and targeted proteomic searches of plasma and cerebrospinal fluid have suggested additional markers that may be useful in sporadic cases of FTLD. While progress has been made in developing biomarkers for FTLD, additional work is needed to extend these advances so that the histopathologic abnormality causing FTLD can be specified in an individual patient.
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页码：366 / 371
页数：5
相关论文
共 325 条
[1]  
Avants B(2007)Spatiotemporal normalization for longitudinal analysis of gray matter atrophy in frontotemporal dementia Med Image Comput Comp Assist Inter 10 309-310
[2]  
Anderson C(2010)Dementia induces correlated reductions in white matter integrity and cortical thickness: a multivariate neuroimaging study with sparse canonical correlation analysis Neuroimage 50 1004-1016
[3]  
Grossman M(2006)Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 Nature 442 916-919
[4]  
Gee JC(2008)Cerebrospinal fluid biomarkers in frontotemporal lobar degeneration with known pathology Neurology 70 1827-1835
[5]  
Avants BB(1999)A clinical pathological comparison of three families with frontotemporal dementia and identical mutations in the tau gene (P301L) Brain 122 741-756
[6]  
Cook PA(2009)Reversal of the concreteness effect in semantic dementia Cogn Neuropsychol 26 568-579
[7]  
Ungar L(2009)Atrophy progression in semantic dementia with asymmetric temporal involvement: a tensor-based morphometry study Neurobiol Aging 30 103-111
[8]  
Gee JC(1999)Inheritance of frontotemporal dementia Arch Neurol 56 817-822
[9]  
Grossman M(2007)Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43 Acta Neuropathol 113 521-533
[10]  
Baker M(2006)Frontotemporal dementia: clinicopathological correlations Ann Neurol 59 952-962
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