Association of circulating metabolites with healthy diet and risk of cardiovascular disease: analysis of two cohort studies

被引:0
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作者
Tasnime Akbaraly
Peter Würtz
Archana Singh-Manoux
Martin J. Shipley
Rita Haapakoski
Maili Lehto
Catherine Desrumaux
Mika Kähönen
Terho Lehtimäki
Vera Mikkilä
Aroon Hingorani
Steve E. Humphries
Antti J. Kangas
Pasi Soininen
Olli Raitakari
Mika Ala-Korpela
Mika Kivimäki
机构
[1] Inserm U 1198,Department of Epidemiology and Public Health, London
[2] University College London,Department of Psychiatry & Autism Resources Centre
[3] Hospital and University Research Center of Montpellier- CHRU-,Computational Medicine, Faculty of Medicine
[4] University of Oulu and Biocenter Oulu,INSERM, U1018, Centre for Research in Epidemiology and Population Health
[5] Hôpital Paul Brousse,Department of Clinical Physiology
[6] University of Tampere School of Medicine and Tampere University Hospital,Department of Clinical Chemistry
[7] Fimlab Laboratories and University of Tampere School of Medicine,Research Centre of Applied and Preventive Cardiovascular Medicine
[8] University of Turku,Centre for Cardiovascular Genetics
[9] British Heart Foundation Laboratories,NMR Metabolomics Laboratory
[10] Institute of Cardiovascular Sciences,Department of Clinical Physiology and Nuclear Medicine
[11] University College London,Department of Epidemiology and Preventive Medicine
[12] School of Pharmacy,Clinicum, Faculty of Medicine
[13] University of Eastern Finland,undefined
[14] Turku University Hospital,undefined
[15] Medical Research Council Integrative Epidemiology Unit at the University of Bristol,undefined
[16] Population Health Science,undefined
[17] Bristol Medical School,undefined
[18] University of Bristol,undefined
[19] Systems Epidemiology,undefined
[20] Baker Heart and Diabetes Institute,undefined
[21] School of Public Health and Preventive Medicine,undefined
[22] Faculty of Medicine,undefined
[23] Nursing and Health Sciences,undefined
[24] The Alfred Hospital,undefined
[25] Monash University,undefined
[26] University of Helsinki,undefined
[27] University Montpellier,undefined
[28] EPHE,undefined
来源
Scientific Reports | / 8卷
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摘要
Diet may modify metabolomic profiles towards higher or lower cardiovascular disease (CVD) risk. We aimed to identify metabolite profiles associated with high adherence to dietary recommendations - the Alternative Healthy Eating Index (AHEI) - and the extent to which metabolites associated with AHEI also predict incident CVD. Relations between AHEI score and 80 circulating lipids and metabolites, quantified by nuclear magnetic resonance metabolomics, were examined using linear regression models in the Whitehall II study (n = 4824, 55.9 ± 6.1 years, 28.0% women) and were replicated in the Cardiovascular Risk in Young Finns Study (n = 1716, 37.7 ± 5.0 years, 56.3% women). We used Cox models to study associations between metabolites and incident CVD over the 15.8-year follow-up in the Whitehall II study. After adjustment for confounders, higher AHEI score (indicating healthier diet) was associated with higher degree of unsaturation of fatty acids (FA) and higher ratios of polyunsaturated FA, omega-3 and docosahexaenoic acid relative to total FA in both Whitehall II and Young Finns studies. A concordance of associations of metabolites with higher AHEI score and lower CVD risk was observed in Whitehall II. Adherence to healthy diet seems to be associated with specific FA that reduce risk of CVD.
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