Enhanced Transdermal Peptide Delivery and Stability by Lipid Conjugation: Epidermal Permeation, Stereoselectivity and Mechanistic Insights

[1] Namjoshi S(2008)Skin peptides: biological activity and therapeutic opportunities J Pharm Sci 97 2524-42

[2] Caccetta R(2008)Proteins and peptides: strategies for delivery to and across the skin J Pharm Sci 97 3591-610

[3] Benson HAE(2012)Lipoamino acids as major components of absorption promoters in drug delivery Curr Top Med Chem 12 1562-80

[4] Benson HAE(2008)Bornyl (3,4,5-trihydroxy)-cinnamate–an optimized human neutrophil elastase inhibitor designed by free energy calculations Bioorg Med Chem 16 2385-90

[5] Namjoshi S(1985)A new class of inhibitors of human leucocyte elastase FEBS Lett 183 201-5

[6] Ziora ZM(1995)Design of potent lipophilic-peptide inhibitors of human neutrophil elastase: In vitro and in vivo studies Int J Pharm 125 117-22

[7] Blaskovich MA(2006)Epidermal penetration of a therapeutic peptide by lipid conjugation; stereo-selective peptide availability of a topical diastereomeric lipopeptide Int J Pept Res Ther 12 327-33

[8] Toth I(2003)Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII J Med Chem 46 1266-72

[9] Cooper MA(1997)Rapid in situ neutralization protocols for Boc and Fmoc solid-phase chemistries Meth Enzymol 289 14-29

[10] Steinbrecher T(1981)Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction Anal Biochem 117 147-57

[1] Namjoshi S(2008)Skin peptides: biological activity and therapeutic opportunities J Pharm Sci 97 2524-42

[2] Caccetta R(2008)Proteins and peptides: strategies for delivery to and across the skin J Pharm Sci 97 3591-610

[3] Benson HAE(2012)Lipoamino acids as major components of absorption promoters in drug delivery Curr Top Med Chem 12 1562-80

[4] Benson HAE(2008)Bornyl (3,4,5-trihydroxy)-cinnamate–an optimized human neutrophil elastase inhibitor designed by free energy calculations Bioorg Med Chem 16 2385-90

[5] Namjoshi S(1985)A new class of inhibitors of human leucocyte elastase FEBS Lett 183 201-5

[6] Ziora ZM(1995)Design of potent lipophilic-peptide inhibitors of human neutrophil elastase: In vitro and in vivo studies Int J Pharm 125 117-22

[7] Blaskovich MA(2006)Epidermal penetration of a therapeutic peptide by lipid conjugation; stereo-selective peptide availability of a topical diastereomeric lipopeptide Int J Pept Res Ther 12 327-33

[8] Toth I(2003)Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII J Med Chem 46 1266-72

[9] Cooper MA(1997)Rapid in situ neutralization protocols for Boc and Fmoc solid-phase chemistries Meth Enzymol 289 14-29

[10] Steinbrecher T(1981)Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction Anal Biochem 117 147-57