Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA1c levels in human pancreatic islets

[1] Ling C(2007)Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle J Clin Invest 117 3427-3435

[2] Poulsen P(2009)Epigenetics: a molecular link between environmental factors and type 2 diabetes Diabetes 58 2718-2725

[3] Simonsson S(2008)Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle Diabetologia 51 1159-1168

[4] Ling C(2009)Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density Cell Metab 10 189-198

[5] Groop L(2008)Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion Diabetologia 51 615-622

[6] Ronn T(2003)Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells J Biol Chem 278 23617-23623

[7] Poulsen P(2007)The human insulin gene displays transcriptionally active epigenetic marks in islet-derived mesenchymal precursor cells in the absence of insulin expression Stem Cells 25 3223-3233

[8] Hansson O(2009)The human insulin gene is part of a large open chromatin domain specific for human islets Proc Natl Acad Sci USA 106 17419-17424

[9] Barres R(2009)Insulin gene expression is regulated by DNA methylation PLoS ONE 4 e6953-220

[10] Osler ME(2010)Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes Science 327 217-100

[1] Ling C(2007)Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle J Clin Invest 117 3427-3435

[2] Poulsen P(2009)Epigenetics: a molecular link between environmental factors and type 2 diabetes Diabetes 58 2718-2725

[3] Simonsson S(2008)Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle Diabetologia 51 1159-1168

[4] Ling C(2009)Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density Cell Metab 10 189-198

[5] Groop L(2008)Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion Diabetologia 51 615-622

[6] Ronn T(2003)Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells J Biol Chem 278 23617-23623

[7] Poulsen P(2007)The human insulin gene displays transcriptionally active epigenetic marks in islet-derived mesenchymal precursor cells in the absence of insulin expression Stem Cells 25 3223-3233

[8] Hansson O(2009)The human insulin gene is part of a large open chromatin domain specific for human islets Proc Natl Acad Sci USA 106 17419-17424

[9] Barres R(2009)Insulin gene expression is regulated by DNA methylation PLoS ONE 4 e6953-220

[10] Osler ME(2010)Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes Science 327 217-100