Top 10 Developments in Lupus Nephritis

被引：0
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作者：
Teresa K. Chen
Derek M. Fine
机构：
[1] The Johns Hopkins University School of Medicine,Division of Nephrology
来源：
Current Rheumatology Reports | 2013年 / 15卷
关键词：
Lupus nephritis; Kidney; Proliferative lupus nephritis; Membranous lupus nephritis; Renal transplantation; Induction therapy; Maintenance therapy; Systemic lupus erythematosus; SLE; Mycophenolate mofetil; Rituximab; Treatment; Multitargeted therapy; Epidemiology;
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摘要：
Lupus nephritis affects up to 60 % of patients with systemic lupus erythematosus and is associated with worse clinical outcomes. Traditionally, it has been treated with high-dose immunosuppression consisting of cyclophosphamide and prednisone; however, recent trials have demonstrated mycophenolate mofetil as a safe and effective alternative for both induction and maintenance of disease. Other progress has been made in our understanding of the pathogenesis of lupus nephritis, outcomes in renal transplantation, and associations with genetic risk factors. This review highlights key developments in our understanding of lupus nephritis over the past decade.
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