Texture analysis with a new method in which the region of interest is segmented into multiple layers for radiofrequency amplitude histogram analysis of fibrous rat livers

被引：4

作者：

Fujii Y. ^{[1
]}

Taniguchi N. ^{[1
]}

Takano R. ^{[2
]}

Wang Y. ^{[1
]}

Shigeta K. ^{[1
]}

Omoto K. ^{[1
]}

Ono T. ^{[1
]}

Satoh I. ^{[1
]}

Itoh K. ^{[1
]}

机构：

[1] Department of Clinical Laboratory Medicine, Jichi Medical School, Kawachi-gun, Tochigi 329-0498, Minamikawachi-machi

[2] Department of Nephrology, Jichi Medical School, Kawachi-gun, Tochigi 329-0498, Minamikawachi-machi

来源：

Journal of Medical Ultrasonics | 2004年 / 31卷 / 1期

关键词：

Fibrous liver; Histogram; Radiofrequency signal; Rat; Tissue characterization; Ultrasound;

D O I：

10.1007/s10396-003-0004-5

中图分类号：

学科分类号：

摘要：

Purpose. The aim of this study was to estimate the severity of fibrosis without a biopsy. Methods. The signal-to-noise ratio (SNR), skewness, and kurtosis were measured using a 10-MHz transducer with the texture analysis in conjunction with an alternative method for evaluating fibrous rat livers. This method segments the region of interest (ROI) into multiple layers (sub-ROIs). In each sub-ROI of a homogeneous medium, the histogram of enveloped amplitude of radiofrequency (RF) backscattered echoes resembles a Rayleigh distribution. In theory, SNR, skewness, and kurtosis for Rayleigh statistics are constant and independent of the mean scattering intensity, which is enhanced by such undesirable effects as tissue attenuation, beam diffraction, and incident waveforms. Thus, these values, which are averages of the corresponding sub-ROI values, constitute an unbiased estimator. All fibrous liver specimens were induced using the dimethylnitrosamine method. Fiber content was estimated quantitatively as the fibrosis index by computer processing of pathological images obtained by light microscopy. Results. The SNR, skewness and kurtosis, expressed as averages of corresponding values from each sub-ROI, correlated closely with the fibrosis index. Conclusion. These results make it possible to predict the severity of liver fibrosis from data obtained without resorting to biopsy. The data, obtained from our earlier study on rats, may be used to evaluate human hepatitis quantitatively by measuring these three values. The method may make it possible to estimate the degree of severity of chronic liver disease noninvasively. © The Japan Society of Ultrasonics in Medicine 2004.

引用

页码：13 / 20

页数：7

共 30 条

[21]

Choji K., Ultrasonography in chronic hepatitis and cirrhosis. Part 1. Semi-quantitative analysis of ultrasonographic findings, Jpn J Med Ultrasonics, 15, pp. 308-316, (1988)

[22]

Choji K., Ultrasonography in chronic hepatitis and cirrhosis. Part 2. Diagnosis by means of a multiple analysis, Jpn J Med Ultrasonics, 15, pp. 317-324, (1988)

[23]

Yamada N., Shinzawa H., Takahashi T., Et al., Ultrasonographical diagnosis of liver cirrhosis using a newly proposed index of liver index. Part 2, Jpn J Med Ultrasonics, 19, pp. 395-402, (1992)

[24]

Asai H., Abdominal Ultrasound Q&A, pp. 37-40, (1992)

[25]

Zimmerman H.J., Handbook of Experimental Pharmacology. Vol 14: Experimental Production of Disease. Part 5: Liver, 14, pp. 1-120, (1796)

[26]

Fujiwara K., Ogata I., Hirata K., Et al., Intravascular coagulation in acute liver failure in rats and its treatment with antithrombin III, Gut, 29, pp. 1103-1108, (1988)

[27]

Jezequel A.M., Mancini R., Rindaldesi M.L., Et al., A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat, J Hepatol, 5, pp. 174-181, (1987)

[28]

Sherlock S., Disease of the Liver and Biliary System, pp. 410-424, (1989)

[29]

Yamaguchi T., Kamiyama N., Hachiya H., Estimation of echo amplitude characteristics of liver using RF signal and b-mode image, J Med Ultrasonics, 27, SUPPL., (2000)

[30]

Dutt V., Greenleaf J.F., Speckle analysis using signal to noise ratios based on fractional order moments, Ultrason Imaging, 17, pp. 251-268, (1995)

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