Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: Human papillomavirus-mediated carcinogenesis

被引：0
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作者：
Liviu Feller
Neil H Wood
Razia AG Khammissa
Johan Lemmer
机构：
[1] University of Limpopo,Department of Periodontology and Oral Medicine
[2] Medunsa Campus,undefined
来源：
Head & Face Medicine | / 6卷
关键词：
Oropharyngeal Squamous Cell Carcinoma; Anal Intraepithelial Neoplasia; Control Cell Cycle Progression; Mediate Cell Proliferation; Infected Epithelial Cell;
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摘要：
High-risk human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV-induced carcinogenesis, and for the maintenance of the consequent neoplastic growth. Cellular transformation is achieved by complex interaction of these oncogenes with several cellular factors of cell cycle regulation including p53, Rb, cyclin-CDK complexes, p21 and p27. Both persistent infection with high-risk HPV genotypes and immune dysregulation are associated with increased risk of HPV-induced squamous cell carcinoma.
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