Induction of Constitutive Androstane Receptor during the Development of Oxidative Stress

被引：0
|
作者：
A. V. Shchul’kin
Yu. V. Abalenikhina
A. A. Seidkulieva
A. N. Ryabkov
E. N. Yakusheva
机构：
[1] Ministry of the Health of the Russian Federation,Ryazan State Medical University
来源：
Bulletin of Experimental Biology and Medicine | 2021年 / 171卷
关键词：
constitutive androstane receptor; oxidative stress; hydrogen peroxide; Caco-2 cell line;
D O I：
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中图分类号：
学科分类号：
摘要：
We studied the effect of 3-, 24-, and 72-h exposure to H2O2 in concentrations of 0.1-100.0 μM on the level of constitutive androstane receptor in Caco-2 cells. It was shown that 3- and 24-h incubation with Н2О2 in all concentrations had no effect on the level of constitutive androstane receptors. Increasing the incubation time to 72 h led to an increase in the level of constitutive androstane receptor at H2O2 concentrations of 5, 10, and 50 μM and to a decrease at a concentration of 100 μM. Antioxidant glutathione (1 mM) in parallel to the prooxidant neutralized these changes.
引用
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页码：615 / 618
页数：3
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