Knockdown of POLQ interferes the development and progression of hepatocellular carcinoma through regulating cell proliferation, apoptosis and migration

被引:0
作者
Qi Pan
Lu Wang
Yu Liu
Min Li
Yao Zhang
Wei Peng
Tan Deng
Mei-Ling Peng
Jin-Qiong Jiang
Jiao Tang
Jingjing Wang
Hua-Xin Duan
Sha-Sha Fan
机构
[1] The First Affiliated Hospital of Hunan Normal University,Oncology Department
[2] Hunan Provincial People’s Hospital,Department of Pathology
[3] Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province,Department of Hepatic Surgery, Department of Oncology
[4] Hunan Normal University,Department of Oncology
[5] The First Affiliated Hospital of Hunan Normal University,undefined
[6] Hunan Provincial People’s Hospital,undefined
[7] Fudan University Shanghai Cancer Center,undefined
[8] Shanghai Medical College,undefined
[9] Fudan University,undefined
[10] The Second Xiangya Hospital of Central South University,undefined
来源
Cancer Cell International | / 21卷
关键词
Hepatocellular carcinoma; POLQ; Cell proliferation; Cell apoptosis; Cell migration;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 173 条
[1]  
Siegel RL(2020)Cancer statistics, 2020 CA A Cancer J Clin 70 7-30
[2]  
Miller KD(2018)Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA A Cancer J Clin 68 394-424
[3]  
Jemal A(2016)Hepatocellular carcinoma: from diagnosis to treatment Surg Oncol 25 74-85
[4]  
Bray F(2018)Systemic therapy for hepatocellular carcinoma: beyond sorafenib Chin Clin Oncol 7 50-236
[5]  
Ferlay J(2018)Hepatocellular carcinoma: review of targeted and immune therapies J Gastrointest Cancer 49 227-549
[6]  
Soerjomataram I(2018)Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine J HEPATOL 68 526-652
[7]  
Siegel RL(2011)Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts J MOL BIOL 405 642-652
[8]  
Torre LA(2011)Lesion bypass activity of DNA polymerase theta (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts J Mol Biol 405 642-3919
[9]  
Jemal A(2010)DNA polymerase θ up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability Proc Natl Acad Sci 107 13390-1613
[10]  
Grandhi M(2019)DNA polymerase θ (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse J Biol Chem 294 3909-3919