Identification of novel inhibitors for TNFα, TNFR1 and TNFα-TNFR1 complex using pharmacophore-based approaches

[1] Sethi G(2009)Targeting TNF for treatment of cancer and autoimmunity Adv Exp Med Biol 647 37-51

[2] Sung B(2000)TNF alpha and the TNF receptor superfamily: structure-function relationship (s) Microsc Res Tech 50 184-195

[3] Kunnumakkara AB(2011)Tumor necrosis factor alpha (TNF-alpha), anti-TNF-alpha and demyelination revisited: an ongoing story J Neuroimmunol 234 1-6

[4] Aggarwal BB(2009)Therapeutic monoclonal antibodies in ophthalmology Prog Retin Eye Res. 28 117-144

[5] Idriss HT(2002)Quantitative assessment of the integrity of the blood-retinal barrier in mice Invest Ophthalmol Vis Sci 43 2462-2467

[6] Naismith JH(2003)Tumour necrosis factor alpha and interleukin 6 gene expression in keratocytes from patients with rheumatoid corneal ulcerations Br J Ophthalmol 87 548-550

[7] Caminero A(2007)Tumor necrosis factor antagonists: preliminary evidence for an emerging approach in the treatment of ocular inflammation Retina 27 399-413

[8] Comabella M(2008)Deleterious role of TNF-alpha in retinal ischemia-reperfusion injury Invest Ophthalmol Vis Sci 49 3605-3610

[9] Montalban X(2012)Regulation of VEGF expression in human retinal cells by cytokines: implications for the role of inflammation in age-related macular degeneration J Cell Physiol 227 116-126

[10] Rodrigues EB(2009)TNF-alpha mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations Mol Vis 15 1418-1428

[1] Sethi G(2009)Targeting TNF for treatment of cancer and autoimmunity Adv Exp Med Biol 647 37-51

[2] Sung B(2000)TNF alpha and the TNF receptor superfamily: structure-function relationship (s) Microsc Res Tech 50 184-195

[3] Kunnumakkara AB(2011)Tumor necrosis factor alpha (TNF-alpha), anti-TNF-alpha and demyelination revisited: an ongoing story J Neuroimmunol 234 1-6

[4] Aggarwal BB(2009)Therapeutic monoclonal antibodies in ophthalmology Prog Retin Eye Res. 28 117-144

[5] Idriss HT(2002)Quantitative assessment of the integrity of the blood-retinal barrier in mice Invest Ophthalmol Vis Sci 43 2462-2467

[6] Naismith JH(2003)Tumour necrosis factor alpha and interleukin 6 gene expression in keratocytes from patients with rheumatoid corneal ulcerations Br J Ophthalmol 87 548-550

[7] Caminero A(2007)Tumor necrosis factor antagonists: preliminary evidence for an emerging approach in the treatment of ocular inflammation Retina 27 399-413

[8] Comabella M(2008)Deleterious role of TNF-alpha in retinal ischemia-reperfusion injury Invest Ophthalmol Vis Sci 49 3605-3610

[9] Montalban X(2012)Regulation of VEGF expression in human retinal cells by cytokines: implications for the role of inflammation in age-related macular degeneration J Cell Physiol 227 116-126

[10] Rodrigues EB(2009)TNF-alpha mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations Mol Vis 15 1418-1428