Effects of Zinc Supplementation on DNA Damage in Rats with Experimental Kidney Deficiency

被引：0
作者：
Sevim Çiftçi Yegin
Semiha Dede
Leyla Mis
Fatmagül Yur
机构：
[1] University of Giresun,Health Service Vocational School of Higher Education
[2] University of Yüzüncü Yıl,Faculty of Veterinary Science, Department of Biochemistry
[3] University of Yüzüncü Yıl,Faculty of Veterinary Science, Department of Physiology
[4] University of Muğla Sıtkı Koçman,Fethiye School of Health, Department of Nutrition and Dietetics
来源：
Biological Trace Element Research | 2017年 / 176卷
关键词：
DNA damage; Renal impair; Zinc;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This study was carried out to determine the effect of zinc on oxidative DNA damage in rats with experimental acute and chronic kidney deficiency. Six groups of five Wistar-Albino rats each were assigned as controls (C), acute kidney deficiency (AKD), zinc-supplemented (+Zn), acute kidney deficiency, zinc-supplemented (AKD + Zn), chronic kidney deficiency (CKD) and zinc-supplemented chronic kidney deficiency (CKD + Zn). The levels of 8-Oxo-2′-deoxyguanosine (8-OHdG) were determined, being the lowest in the CKD group (p < 0.05), higher in the C group than those of rats with CKD but lower than that of all the other groups (p < 0.05). There were no significant differences between the controls and the CKD + Zn group, or between the AKD and the +Zn groups. Among all groups, the highest 8-OHdG level was found in the AKD + Zn group (p < 0.05). DNA damage was greater in acute renal failure than in rats with chronic renal failure. The DNA damage in the zinc group was significantly higher than in the controls.
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页码：338 / 341
页数：3
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