Efficacy of snakehead fish (Channa striatus) in subjects with allergic rhinitis: a randomized controlled trial

被引:5
作者
Susibalan B.D. [1 ,2 ]
Abdullah B. [1 ,2 ]
Mat Lazim N. [1 ,2 ]
Abdul Kadir A. [2 ,3 ]
机构
[1] Department of Otorhinolaryngology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan
[2] Hospital Universiti Sains Malaysia, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan
[3] Department of Family Medicine, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan
来源
Oriental Pharmacy and Experimental Medicine | 2018年 / 18卷 / 3期
关键词
Allergic rhinitis; Channa striatus; Immunoglobulin E; Nasal symptoms score;
D O I
10.1007/s13596-018-0327-9
中图分类号
学科分类号
摘要
Allergic rhinitis is a prevailing chronic inflammatory respiratory disorder that affects 10–30% of the population globally. Channa striatus (Channa) is a snakehead, freshwater fish that has been used traditionally to enhance wound healing and relief post-operative pain. This study evaluates the efficacy of oral Channa extract on allergic rhinitis subjects on total nasal symptom score and serum immunoglobulin E (Ig E). A randomized, double-blind, placebo-controlled trial was conducted by comparing the oral Channa extract 500 mg/day and placebo among allergic rhinitis subjects for a 6-week intervention period. Subjects aged 18–50 years old, diagnosed with allergic rhinitis based on total symptoms score, naso-endoscopy findings, and positive skin prick test were included in this trial. All subjects were treated with antihistamine (levocetrizine) and local corticosteroid nasal spray (fluticasone furoate nasal spray). Laboratory-based blood tests were used as safety measures. A total of 70 subjects were randomized. Channa group showed significant improvement in nasal blockage (p < 0.05), nasal itchiness (p < 0.05), eye itchiness (p < 0.05) and general symptoms (p < 0.05) compared to the placebo groups. Serum Ig E were significantly lowered in Channa group compared to placebo (p < 0.001). No significant differences were found between the groups in terms of nasal discharge, sneezing, palate itchiness, and smell score. No serious adverse events were reported. In conclusion, Channa has a beneficial role in improving nasal symptoms and reduction in serum Ig E in allergic rhinitis subjects. © 2018, Institute of Korean Medicine, Kyung Hee University and Springer Science+Business Media B.V., part of Springer Nature.
引用
收藏
页码:209 / 215
页数:6
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