Stress-Induced Immune Dysregulation: Implications for Wound Healing, Infectious Disease and Cancer

被引：0
作者：
Jonathan P. Godbout
Ronald Glaser
机构：
[1] Ohio State University,Institute for Behavioral Medicine Research
[2] Ohio State University,Department of Molecular Virology, Immunology, and Medical Genetics
[3] Ohio State University,Comprehensive Cancer Center
[4] Ohio State University,undefined
来源：
Journal of Neuroimmune Pharmacology | 2006年 / 1卷
关键词：
stress; immunity; cytokines; behavior;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The communication between the central nervous system and the immune system occurs via a complex network of bidirectional signals linking the nervous, endocrine and immune systems. The field of psychoneuroimmunology (PNI) has provided new insights to help understand the pathophysiological processes that are linked to the immune system. Work in this field has established that psychological stress disrupts the functional interaction between the nervous and immune systems. Stress-induced immune dysregulation has been shown to be significant enough to result in health consequences, including reducing the immune response to vaccines, slowing wound healing, reactivating latent herpesviruses, such as Epstein–Barr virus (EBV), and enhancing the risk for more severe infectious disease. Chronic stress/depression can increase the peripheral production of proinflammatory cytokines, such as interleukin (IL)-6. High serum levels of IL-6 have been linked to risks for several conditions, such as cardiovascular disease, type 2 diabetes, mental health complications, and some cancers. This overview will discuss the evidence that psychological stress promotes immune dysfunction that negatively impacts human health.
引用
收藏
页码：421 / 427
页数：6
相关论文
共 391 条
  • [51] Kemeny ME(1999)Psychological stress and antibody response to influenza vaccination: when is the critical period for stress, and how does it get inside the body? J Psychiatr Res 33 389-395
  • [52] Taylor SE(2003)Psychological variables as predictors of rubella antibody titers and fatigue—a prospective, double blind study Trends Immunol 24 444-448
  • [53] Visscher BR(1998)How stress influences the immune response Brain Behav Immun 12 64-73
  • [54] Fahey JL(1998)Restraint stress slows cutaneous wound healing in mice Proc Natl Acad Sci USA 95 7231-7235
  • [55] De Bosscher K(2004)Social stress and the reactivation of latent herpes simplex virus type 1 J Med Virol 74 442-448
  • [56] Vanden Berghe W(1994)Epstein–Barr virus-encoded dUTPase modulates immune function and induces sickness behavior in mice JAMA 272 1700-1701
  • [57] Vermeulen L(1999)A randomized controlled trial of influenza vaccine in the elderly. Scientific scrutiny and ethical responsibility Aviat Space Environ Med 70 1211-1213
  • [58] Plaisance S(2003)Incidence of Epstein–Barr virus in astronaut saliva during spaceflight Biol Psychiatry 54 566-572
  • [59] Boone E(1997)Inflammatory markers and depressed mood in older persons: results from the Health, Aging and Body Composition study Anticancer Res 17 3907-3913
  • [60] Haegeman G(2005)Implication of the Epstein–Barr virus in the progression of chronic lymphocytic leukaemia/small lymphocytic lymphoma to Hodgkin-like lymphomas Brain Behav Immun 19 235-242
12345678910