Stress-Induced Immune Dysregulation: Implications for Wound Healing, Infectious Disease and Cancer

被引：0
作者：
Jonathan P. Godbout
Ronald Glaser
机构：
[1] Ohio State University,Institute for Behavioral Medicine Research
[2] Ohio State University,Department of Molecular Virology, Immunology, and Medical Genetics
[3] Ohio State University,Comprehensive Cancer Center
[4] Ohio State University,undefined
来源：
Journal of Neuroimmune Pharmacology | 2006年 / 1卷
关键词：
stress; immunity; cytokines; behavior;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The communication between the central nervous system and the immune system occurs via a complex network of bidirectional signals linking the nervous, endocrine and immune systems. The field of psychoneuroimmunology (PNI) has provided new insights to help understand the pathophysiological processes that are linked to the immune system. Work in this field has established that psychological stress disrupts the functional interaction between the nervous and immune systems. Stress-induced immune dysregulation has been shown to be significant enough to result in health consequences, including reducing the immune response to vaccines, slowing wound healing, reactivating latent herpesviruses, such as Epstein–Barr virus (EBV), and enhancing the risk for more severe infectious disease. Chronic stress/depression can increase the peripheral production of proinflammatory cytokines, such as interleukin (IL)-6. High serum levels of IL-6 have been linked to risks for several conditions, such as cardiovascular disease, type 2 diabetes, mental health complications, and some cancers. This overview will discuss the evidence that psychological stress promotes immune dysfunction that negatively impacts human health.
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页码：421 / 427
页数：6
相关论文
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  • [1] Altemus M(2001)Stress-induced changes in skin barrier function in healthy women J Invest Dermatol 117 309-317
  • [2] Rao B(1999)Epstein–Barr virus infection in Richter's transformation Am J Hematol 60 99-104
  • [3] Dhabhar FS(1991)Stress-induced suppression of herpes simplex virus (HSV)-specific cytotoxic T lymphocyte and natural killer cell activity and enhancement of acute pathogenesis following local HSV infection Brain Behav Immun 5 170-192
  • [4] Ding W(1993)Stress-induced modulation of the primary cellular immune response to herpes simplex virus infection is mediated by both adrenal-dependent and independent mechanisms J Neuroimmunol 42 167-176
  • [5] Granstein RD(2002)Is the Epstein–Barr virus infection relevant in lymphomagenesis? Hum Pathol 33 143-145
  • [6] Ansell SM(2002)Perceived stress and psychological well-being are associated with antibody status after meningitis C conjugate vaccination Psychosom Med 64 963-970
  • [7] Li CY(2002)Autonomic and glucocorticoid associations with the steady-state expression of latent Epstein–Barr virus Horm Behav 42 32-41
  • [8] Lloyd RV(1998)Social stress results in altered glucocorticoid regulation and shorter survival in simian acquired immune deficiency syndrome Proc Natl Acad Sci USA 95 4714-4719
  • [9] Phyliky RL(1991)Psychological stress and susceptibility to the common cold N Engl J Med 325 606-612
  • [10] Bonneau RH(1998)Types of stressors that increase susceptibility to the common cold in healthy adults Health Psychol 17 214-223
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