HIF-1α overexpression in mesenchymal stem cell-derived exosomes mediates cardioprotection in myocardial infarction by enhanced angiogenesis

被引:0
作者
Jiacheng Sun
Han Shen
Lianbo Shao
Xiaomei Teng
Yueqiu Chen
Xuan Liu
Ziying Yang
Zhenya Shen
机构
[1] Soochow University,Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science
来源
Stem Cell Research & Therapy | / 11卷
关键词
HIF-1α; Exosome; Mesenchymal stem cell; Myocardial infarction; Angiogenesis;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 44 条
[21]  
Wang X(2017)Curcumin induces therapeutic angiogenesis in a diabetic mouse hindlimb ischemia model via modulating the function of endothelial progenitor cells Stem Cell Res Ther 8 1310-257
[22]  
Chen Y(2007)Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia Circ Res 101 2670-864
[23]  
Jeppesen DK(2013)Proteome analysis reveals antiangiogenic environments in chronic wounds of diabetes mellitus type 2 patients Proteomics 13 2415-571
[24]  
You J(2015)Mesenchymal stem cell-derived exosomes improve the microenvironment of infarcted myocardium contributing to angiogenesis and anti-inflammation Cell Physiol Biochem 37 373-C320
[25]  
Bosch-Marce M(2013)Extracellular vesicles: exosomes, microvesicles, and friends J Cell Biol 200 51-2124
[26]  
Krisp C(2017)Exosomes derived from Akt-modified human umbilical cord mesenchymal stem cells improve cardiac regeneration and promote angiogenesis via activating platelet-derived growth factor D Stem Cells Transl Med 6 659890-3471
[27]  
Teng X(2015)Exosomes secreted from CXCR4 overexpressing mesenchymal stem cells promote cardioprotection via Akt signaling pathway following myocardial infarction Stem Cells Int 2015 1085-748
[28]  
Raposo G(2010)Hypoxia inducible factor 1 (HIF-1) and cardioprotection Acta Pharmacol Sin 31 79-undefined
[29]  
Stoorvogel W(2003)Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury Circulation 108 604-undefined
[30]  
Ma J(2003)Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2 Nat Med 9 249-undefined