Mitemcinal (GM-611), an orally active motilin receptor agonist, accelerates colonic motility and bowel movement in conscious dogs

被引：16

作者：

Ozaki K. ^{[1
]}

Sudo H. ^{[1
]}

Muramatsu H. ^{[1
]}

Yogo K. ^{[1
]}

Kamei K. ^{[1
]}

Koga H. ^{[1
]}

Itoh Z. ^{[2
]}

Ōmura S. ^{[3
]}

Takanashi H. ^{[1
,4
]}

机构：

[1] Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., Gotemba

[2] Gunma University, Maebashi

[3] Kitasato Institute, Minato-ku

[4] Targeted Disease Areas Department, Chugai Pharmaceutical Co., Ltd., Chuo-ku, Tokyo 103-8324

来源：

Inflammopharmacology | 2007年 / 15卷 / 1期

关键词：

Bowel movement; Colon; Constipation; Diarrhea; GM-611; Mitemcinal; Motilin; Motility;

D O I：

10.1007/s10787-006-1542-4

中图分类号：

学科分类号：

摘要：

The prokinetic effects of mitemcinal, an orally active motilin receptor agonist, on the lower gastrointestinal tracts were investigated in conscious dogs. Oral administration of mitemcinal (0.1-1 mg/kg) stimulated colonic motility, which was measured by chronically implanted force-transducers, as well as gastric motility in a dose-dependent manner. The gastrointestinal contractile activities induced by mitemcinal were inhibited by the continuous intravenous infusion of GM-109, a selective motilin receptor antagonist. Oral administration of mitemcinal (0.3-3 mg/kg) also accelerated bowel movement after feeding without inducing diarrhea in dogs. The results demonstrate that mitemcinal stimulates colonic motility via motilin receptors and the effect of mitemcinal on colonic motility may reflect bowel movement after feeding. Thus, mitemcinal could be a promising agent for treatment of not only the upper but also the lower gastrointestinal motility disorders. © 2007 Birkhäuser Verlag.

引用

页码：36 / 42

页数：6

共 22 条

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