The specific character of the reaction of derivatives of 2-thioxo-2,3-dihydropyrimidin-4(1H)-one with iodomethane and alkyl chloromethyl sulfides

被引：0
|
作者：
I. A. Novakov
B. S. Orlinson
M. B. Nawrozkij
A. Mai
M. Artico
D. Rotili
A. S. Eremiychuk
E. A. Gordeeva
L. L. Brunilina
J. A. Este
机构：
[1] Volgograd State Technical University,Istituto Pasteur – Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici
[2] Università degli Studidi Roma “La Sapienza”,Retrovirology Laboratory IrsiCaixa, Hospital Universitari Germans Trias i Pujol
[3] Universitat Autònoma de Barcelona,undefined
来源：
Chemistry of Heterocyclic Compounds | 2010年 / 46卷
关键词：
5-alkyl-6-(2,6-dihalobenzyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-ones; allyl chloro-methyl sulfide; iodomethane; methyl chloromethyl sulfide; S; 1- and S; 2-substitution; anti-HIV-1 agents;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The alkylation of 5-alkyl-6-(2,6-dihalobenzyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-ones with MeI, AllSCH2Cl, and MeSCH2Cl in the K2CO3–DMF, NaOMe–MeOH, and KOH–EtOH systems was investigated. A hypothetical mechanism for the reaction is examined, and an explanation is proposed for the composition of the reaction products. The presence of high anti-HIV-1 activity was established in the obtained derivatives of 2-{[(allylsulfanyl)methyl]sulfanyl}pyrimidin-4(3H)-one.
引用
收藏
页码：200 / 205
页数：5
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