Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression

被引：0
作者：
Jodi L. Pawluski
Ursula Brain
Geoffrey L. Hammond
Tim F. Oberlander
机构：
[1] University Rennes,Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail)
[2] The University of British Columbia,Department of Pediatrics, BC Children’s Hospital
[3] The University of British Columbia,Department of Cellular and Physiological Sciences, Faculty of Medicine
来源：
Archives of Women's Mental Health | 2019年 / 22卷
关键词：
Depression; Anxiety; Antidepressants; Gestation; Motherhood; Neuroplasticity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The effect of perinatal selective serotonin reuptake inhibitors (SSRIs) on brain-derived neurotrophic factor (BDNF) and S100 calcium binding protein B (S100B) has not been investigated. Using a cohort of 86 pregnant women, we found that SSRIs significantly increase BDNF levels in late pregnancy and that S100B, but not BDNF, is associated with maternal depression in SSRI-treated women only. This shows that serum S100B could be a unique biomarker to determine efficacy of SSRIs during gestation.
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页码：431 / 435
页数：4
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