Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression

被引：0
作者：
Jodi L. Pawluski
Ursula Brain
Geoffrey L. Hammond
Tim F. Oberlander
机构：
[1] University Rennes,Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail)
[2] The University of British Columbia,Department of Pediatrics, BC Children’s Hospital
[3] The University of British Columbia,Department of Cellular and Physiological Sciences, Faculty of Medicine
来源：
Archives of Women's Mental Health | 2019年 / 22卷
关键词：
Depression; Anxiety; Antidepressants; Gestation; Motherhood; Neuroplasticity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The effect of perinatal selective serotonin reuptake inhibitors (SSRIs) on brain-derived neurotrophic factor (BDNF) and S100 calcium binding protein B (S100B) has not been investigated. Using a cohort of 86 pregnant women, we found that SSRIs significantly increase BDNF levels in late pregnancy and that S100B, but not BDNF, is associated with maternal depression in SSRI-treated women only. This shows that serum S100B could be a unique biomarker to determine efficacy of SSRIs during gestation.
引用
收藏
页码：431 / 435
页数：4
相关论文
共 84 条
[1]  
aan het Rot M(2009)Neurobiological mechanisms in major depressive disorder CMAJ 180 305-313
[2]  
Mathew SJ(2015)Antenatal maternal antidepressants drugs affect S100B concentrations in fetal-maternal biological fluids CNS Neurol Disord Drug Targets 14 49-54
[3]  
Charney DS(2003)Reference values for serum S-100B protein depend on the race of individuals Clin Chem 49 836-837
[4]  
Bellissima V(2007)Role of neurotrophic factors in depression Curr Opin Pharmacol 7 18-21
[5]  
Visser GH(2016)Serum brain-derived neurotrophic factor (BDNF) across pregnancy and postpartum: associations with race, depressive symptoms, and low birth weight Psychoneuroendocrinology 74 69-76
[6]  
Ververs TF(2006)A neurotrophic model for stress-related mood disorders Biol Psychiatry 59 1116-1127
[7]  
Bel F(2016)Serum BDNF concentration after delivery is associated with development of postpartum depression: a 3-month follow up study J AffectDisord 200 25-30
[8]  
Termote JU(2017)Effect of agomelatine and fluoxetine on HAM-D score, serum brain-derived neurotrophic factor, and tumor necrosis factor-alpha level in patients with major depressive disorder with severe depression J Clin Pharmacol 57 1519-1526
[9]  
Heide M(2006)Maternal serum concentrations of BDNF and depression in the perinatal period Psychoneuroendocrinology 31 388-394
[10]  
Gazzolo D(2005)The impact of age, weight and gender on BDNF levels in human platelets and plasma Neurobiol Aging 26 115-123
123456789