Management of Acute Liver Failure: A Pediatric Perspective

被引：30
作者：
Bhatt H. [1 ]
Rao G.S. [1 ]
机构：
[1] Section of Pediatric Gastroenterology, Hepatology and Nutrition, Riley Hospital for Children, Indiana University School of Medicine, Indiana University, 705 Riley Hospital Drive, ROC 4210, Indianapolis, 46202, IN
来源：
Current Pediatrics Reports | 2018年 / 6卷 / 3期
关键词：
Acute liver failure; Coagulopathy; Hepatic encephalopathy; Liver transplantation; Multi-organ system failure; Pediatric;
D O I：
10.1007/s40124-018-0174-7
中图分类号：
学科分类号：
摘要：
Purpose of Review: Pediatric acute liver failure is a rare, complex, rapidly progressing, and life-threatening illness. Majority of pediatric acute liver failures have unknown etiology. This review intends to discuss the current literature on the challenging aspects of management of acute liver failure. Recent Findings: Collaborative multidisciplinary approach for management of patients with pediatric acute liver failure with upfront involvement of transplant hepatologist and critical care specialists can improve outcomes of this fatal disease. Extensive but systematic diagnostic evaluation can help to identify etiology and guide management. Early referral to a transplant center with prompt liver transplant, if indicated, can lead to improved survival in these patients. Summary: Prompt identification and aggressive management of pediatric acute liver failure and related comorbidities can lead to increased transplant-free survival and improved post-transplant outcomes, thus decreasing mortality and morbidity associated with this potential fatal condition. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
引用
收藏
页码：246 / 257
页数：11
相关论文
共 80 条
[1]  
Liver Disease in Children, (2014)
[2]  
Lutfi R., Abulebda K., Nitu M.E., Molleston J.P., Bozic M.A., Subbarao G., Intensive care management of pediatric acute liver failure, J Pediatr Gastroenterol Nutr, 64, 5, pp. 660-670, (2017)
[3]  
Squires R.H., Acute liver failure in children, Semin Liver Dis, 28, 2, pp. 153-166, (2008)
[4]  
Kim W.R., Lake J.R., Smith J.M., Skeans M.A., Schladt D.P., Edwards E.B., Harper A.M., Wainright J.L., Snyder J.J., Israni A.K., Kasiske B.L., OPTN/SRTR 2015 Annual Data Report: liver, Am J Transplant, 17, pp. 174-251, (2017)
[5]  
Narkewicz M.R., Dell Olio D., Karpen S.J., Murray K.F., Schwarz K., Yazigi N., Et al., Pattern of diagnostic evaluation for the causes of pediatric acute liver failure: an opportunity for quality improvement, J Pediatr, 155, 6, pp. 801-806, (2009)
[6]  
Sundaram S.S., Alonso E.M., Narkewicz M.R., Zhang S., Squires R.H., Characterization and outcomes of young infants with acute liver failure, J Pediatr, 159, 5, pp. 813-818, (2011)
[7]  
Schwarz K.B., Olio D.D., Lobritto S.J., Lopez M.J., Rodriguez-Baez N., Yazigi N.A., Et al., Analysis of viral testing in nonacetaminophen pediatric acute liver failure, J Pediatr Gastroenterol Nutr, 59, 5, pp. 616-623, (2014)
[8]  
Bucuvalas J., Yazigi N., Squires R.H., Acute liver failure in children, Clin Liver Dis, 10, 1, pp. 149-168, (2006)
[9]  
Lee W.M., Larson A.M., Stravitz R.T., (2011)
[10]  
Singhal A., Vadlamudi S., Stokes K., Cassidy F.P., Corn A., Shrago S.S., Wright H.I., Kohli V., Liver histology as predictor of outcome in patients with acute liver failure, Transpl Int, 25, 6, pp. 658-662, (2012)
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